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    Identifying unmet needs and challenges in the definition of a plaque in mycosis fungoides: an EORTC-CLG/ISCL survey

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    Authors
    Quaglino, P.
    Scarisbrick, J.
    Roccuzzo, G.
    Abeldano, A.
    Battistella, M.
    McCormack, C.
    Cowan, Richard A
    Cozzio, A.
    Cury-Martins, J.
    Enz, P.
    Geskin, L.
    Guenova, E.
    Kim, Y. H.
    Knobler, R.
    Litvinov, I. V.
    Miyagaki, T.
    Molgo, M.
    Nicolay, J.
    Papadavid, E.
    Pinter-Brown, L.
    Pujol Vallverdu, R.
    Querfeld, C.
    Ortiz-Romero, P.
    Stadler, R.
    Vermeer, M.
    Bagot, M.
    Hodak, E.
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    Affiliation
    Dermatologic Clinic, Department of Medical Sciences, University of Torino, Torino, Italy
    Issue Date
    2023
    
    Metadata
    Show full item record
    Abstract
    Background: Consensus about the definition and classification of "plaque" in mycosis fungoides is lacking. Objectives: To delineate a comprehensive view on how the "plaque" entity is defined and managed in clinical practice; to evaluate whether the current positioning of plaques in the TNMB classification is adequate. Methods: A 12-item survey was circulated within a selected panel of 22 experts (pathologists, dermatologists, hematologists, oncologists), members of the EORTC and International Society for Cutaneous Lymphoma. The questionnaire discussed clinical and histopathological definitions of plaques and its relationship with staging and treatment. Results: Total consensus and very high agreement rates were reached in 33.3% of questions, as all panelists regularly check for the presence of plaques, agree to evaluate the presence of plaques as a potential separate T class, and concur on the important distinction between plaque and patch for the management of early-stage MF. High agreement was reached in 41.7% of questions, since more than 50% of the responders use Olsen's definition of plaque, recommend the distinction between thin/thick plaques, and agree on performing a biopsy on the most infiltrated/indurated lesion. High divergence rates (25%) were reported regarding the possibility of a clinically based distinction between thin and thick plaques and the role of histopathology to plaque definition. Conclusions: The definition of "plaque" is commonly perceived as a clinical entity and its integration with histopathological features is generally reserved to specific cases. To date, no consensus is achieved as for the exact definition of thin and thick plaques and current positioning of plaques within the TNMB system is considered clinically inadequate. Prospective studies evaluating the role of histopathological parameters and other biomarkers, as well as promising diagnostic tools, such as US/RM imaging and high throughput blood sequencing, are much needed to fully integrate current clinical definitions with more objective parameters.
    Citation
    Quaglino P, Scarisbrick J, Roccuzzo G, Abeldano A, Battistella M, McCormack C, et al. Identifying unmet needs and challenges in the definition of a plaque in mycosis fungoides: an EORTC-CLG/ISCL survey. Journal of the European Academy of Dermatology and Venereology : JEADV. 2023 Jan 6. PubMed PMID: 36606565. Epub 2023/01/07. eng.
    Journal
    Journal of the European Academy of Dermatology and Venereology
    URI
    http://hdl.handle.net/10541/625940
    DOI
    10.1111/jdv.18852
    PubMed ID
    36606565
    Additional Links
    https://dx.doi.org/10.1111/jdv.18852
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/jdv.18852
    Scopus Count
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