Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma
dc.contributor.author | Stubbs, M. A. | |
dc.contributor.author | Clark, V. L. | |
dc.contributor.author | Gibson, P. G. | |
dc.contributor.author | Yorke, Janelle | |
dc.contributor.author | McDonald, V. M. | |
dc.date.accessioned | 2023-01-16T14:12:54Z | |
dc.date.available | 2023-01-16T14:12:54Z | |
dc.date.issued | 2022 | en |
dc.identifier.citation | Stubbs MA, Clark VL, Gibson PG, Yorke J, McDonald VM. Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma. Respiratory research. 2022 Dec 12;23(1):341. PubMed PMID: 36510255. Epub 2022/12/13. eng. | en |
dc.identifier.pmid | 36510255 | en |
dc.identifier.doi | 10.1186/s12931-022-02266-5 | en |
dc.identifier.uri | http://hdl.handle.net/10541/625894 | |
dc.description.abstract | Background: Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood. The study objective is to determine clinical characteristics associated with anxiety and depressive symptoms in severe asthma. Methods: Severe asthma participants (N = 140) underwent a multidimensional assessment. Categorization of symptoms of anxiety and depression were based on HADS scale sub-scores and divided into four groups (< 8 on both subscales; ≥ 8 on one subscale; ≥ 8 on both subscales). Clinical characteristics were compared between subgroups. Multivariate logistic regression determined associations of clinical characteristics and anxiety and/or depressive symptoms in people with severe asthma. Results: Participants were (mean ± SD) 59.3 ± 14.7 years old, and 62% female. There were 74 (53%) severe asthma participants without symptoms of anxiety/depression, 11 (7%) with symptoms of anxiety, 37 (26%) with symptoms of depression and 18 (13%) with symptoms of anxiety and depression. Quality of life impairment was greater in participants with symptoms of depression (4.4 ± 1.2) and combined symptoms of anxiety and depression (4.4 ± 1.1). Asthma control was worse in those with symptoms of depression (2.9 ± 1.1) and combined anxiety and depression (2.6 ± 1.0). In multivariate models, dysfunctional breathing was associated with symptoms of anxiety (OR = 1.24 [1.01, 1.53]). Dyspnoea was associated with symptoms of depression (OR = 1.90 [1.10, 3.25]). Dysfunctional breathing (OR 1.16 [1.04, 1.23]) and obesity (OR 1.17 [1.00, 1.35]) were associated with combined symptoms of anxiety and depression. Conclusion: People with severe asthma and anxiety and/or depressive symptoms have poorer QoL and asthma control. Dyspnoea, dysfunctional breathing and obesity are associated with these symptoms. These key clinical characteristics should be targeted in severe asthma management. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1186/s12931-022-02266-5 | en |
dc.title | Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma | en |
dc.type | Article | en |
dc.contributor.department | National Health and Medical Research Council Centre for Research Excellence in Severe Asthma, Level 2 West Wing, 1 Kookaburra Circuit, New Lambton Heights, NSW, 2305, Australia. | en |
dc.identifier.journal | Respiratory Research | en |
dc.description.note | en] | |
refterms.dateFOA | 2023-01-17T10:22:37Z |