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dc.contributor.authorStubbs, M. A.
dc.contributor.authorClark, V. L.
dc.contributor.authorGibson, P. G.
dc.contributor.authorYorke, Janelle
dc.contributor.authorMcDonald, V. M.
dc.date.accessioned2023-01-16T14:12:54Z
dc.date.available2023-01-16T14:12:54Z
dc.date.issued2022en
dc.identifier.citationStubbs MA, Clark VL, Gibson PG, Yorke J, McDonald VM. Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma. Respiratory research. 2022 Dec 12;23(1):341. PubMed PMID: 36510255. Epub 2022/12/13. eng.en
dc.identifier.pmid36510255en
dc.identifier.doi10.1186/s12931-022-02266-5en
dc.identifier.urihttp://hdl.handle.net/10541/625894
dc.description.abstractBackground: Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood. The study objective is to determine clinical characteristics associated with anxiety and depressive symptoms in severe asthma. Methods: Severe asthma participants (N = 140) underwent a multidimensional assessment. Categorization of symptoms of anxiety and depression were based on HADS scale sub-scores and divided into four groups (< 8 on both subscales; ≥ 8 on one subscale; ≥ 8 on both subscales). Clinical characteristics were compared between subgroups. Multivariate logistic regression determined associations of clinical characteristics and anxiety and/or depressive symptoms in people with severe asthma. Results: Participants were (mean ± SD) 59.3 ± 14.7 years old, and 62% female. There were 74 (53%) severe asthma participants without symptoms of anxiety/depression, 11 (7%) with symptoms of anxiety, 37 (26%) with symptoms of depression and 18 (13%) with symptoms of anxiety and depression. Quality of life impairment was greater in participants with symptoms of depression (4.4 ± 1.2) and combined symptoms of anxiety and depression (4.4 ± 1.1). Asthma control was worse in those with symptoms of depression (2.9 ± 1.1) and combined anxiety and depression (2.6 ± 1.0). In multivariate models, dysfunctional breathing was associated with symptoms of anxiety (OR = 1.24 [1.01, 1.53]). Dyspnoea was associated with symptoms of depression (OR = 1.90 [1.10, 3.25]). Dysfunctional breathing (OR 1.16 [1.04, 1.23]) and obesity (OR 1.17 [1.00, 1.35]) were associated with combined symptoms of anxiety and depression. Conclusion: People with severe asthma and anxiety and/or depressive symptoms have poorer QoL and asthma control. Dyspnoea, dysfunctional breathing and obesity are associated with these symptoms. These key clinical characteristics should be targeted in severe asthma management.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1186/s12931-022-02266-5en
dc.titleAssociations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthmaen
dc.typeArticleen
dc.contributor.departmentNational Health and Medical Research Council Centre for Research Excellence in Severe Asthma, Level 2 West Wing, 1 Kookaburra Circuit, New Lambton Heights, NSW, 2305, Australia.en
dc.identifier.journalRespiratory Researchen
dc.description.noteen]
refterms.dateFOA2023-01-17T10:22:37Z


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