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dc.contributor.authorHeumann, P.
dc.contributor.authorAguado-Barrera, M. E.
dc.contributor.authorAvuzzi, B.
dc.contributor.authorAzria, D.
dc.contributor.authorBriers, E.
dc.contributor.authorBultijnck, R.
dc.contributor.authorChoudhury, Ananya
dc.contributor.authorDe Ruysscher, D.
dc.contributor.authorFarcy-Jacquet, M. P.
dc.contributor.authorFonteyne, V.
dc.contributor.authorGómez Caamaño, A.
dc.contributor.authorHelmbold, I.
dc.contributor.authorJohnson, K.
dc.contributor.authorKerns, S. L.
dc.contributor.authorLambrecht, M.
dc.contributor.authorLingard, Zoe
dc.contributor.authorRancati, T.
dc.contributor.authorRosenstein, B. S.
dc.contributor.authorSperk, E.
dc.contributor.authorPaul Symonds, R.
dc.contributor.authorTalbot, C.
dc.contributor.authorValdagni, R.
dc.contributor.authorVega, A.
dc.contributor.authorVeldeman, L.
dc.contributor.authorWard, T.
dc.contributor.authorWebb, A.
dc.contributor.authorWest, Catharine M L
dc.contributor.authorChang-Claude, J.
dc.contributor.authorSeibold, P.
dc.date.accessioned2023-01-16T14:12:48Z
dc.date.available2023-01-16T14:12:48Z
dc.date.issued2022en
dc.identifier.citationHeumann P, Aguado-Barrera ME, Avuzzi B, Azria D, Briers E, Bultijnck R, et al. Comparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE study. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2022 Nov 25;178:109426. PubMed PMID: 36442608. Epub 2022/11/29. eng.en
dc.identifier.pmid36442608en
dc.identifier.doi10.1016/j.radonc.2022.11.015en
dc.identifier.urihttp://hdl.handle.net/10541/625876
dc.description.abstractIntroduction: Previous studies showed that healthcare professionals and patients had only moderate to low agreement on their assessment of treatment-related symptoms. We aimed to determine the levels of agreement in a large cohort of prostate cancer patients. Methods: Analyses were made of data from 1,756 prostate cancer patients treated with external beam radiotherapy (RT) and/or brachytherapy in Europe and the USA and recruited into the prospective multicentre observational REQUITE study. Eleven pelvic symptoms at the end of RT were compared after translating patient-reported outcomes (PROs) into CTCAE-based healthcare professional ratings. Gwet's AC2 agreement coefficient and 95% confidence intervals were calculated for each symptom. To compare severity of grading between patients and healthcare professionals, percent agreement and deviations for each symptom were graphically depicted. Stratified and sensitivity analyses were conducted to identify potential influencing factors and to assess heterogeneity and robustness of results. Results: The agreement for the 11 pelvic symptoms varied from very good (AC2 > 0.8: haematuria, rectal bleeding, management of sphincter control) to poor agreement (AC2 ≤ 0.2: proctitis and urinary urgency). Fatigue had a negative impact on the agreement. Patients tended to grade symptoms more severely than healthcare professionals. Information on sexual dysfunction was missing more frequently in healthcare professional assessment than PROs. Conclusion: Agreement was better for observable than subjective symptoms, with patients usually grading symptoms more severely than healthcare professionals. Our findings emphasize that PROs should complement symptom assessment by healthcare professionals and be taken into consideration for clinical decision-making to incorporate the patient perspective.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.radonc.2022.11.015en
dc.titleComparing symptom reporting by prostate cancer patients and healthcare professionals in the international multicentre REQUITE studyen
dc.typeArticleen
dc.contributor.departmentGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germanyen
dc.identifier.journalRadiotherapy and Oncologyen
dc.description.noteen]
refterms.dateFOA2023-01-17T09:57:21Z


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