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    Use of antihypertensive drugs and risk of cutaneous melanoma: a nationwide nested case-control study

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    Authors
    Ghiasvand, R.
    Berge, L. A. M.
    Andreassen, B. K.
    Stenehjem, J. S.
    Heir, T.
    Karlstad, Ø.
    Juzeniene, A.
    Larsen, I. K.
    Green, Adèle C
    Veierød, M. B.
    Robsahm, T. E.
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    Affiliation
    Department of Research, Cancer Registry of Norway, Oslo, Norway
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Background: Most antihypertensives can induce dermal photosensitivity, which may increase melanoma risk. However, corroborating evidence is limited. We examined the associations between use of antihypertensives and melanoma risk. Methods: A nationwide nested case-control study was conducted using data from the Cancer Registry of Norway, the National Registry and the Norwegian Prescription Database in 2004-15. Ten controls were randomly selected for each melanoma case, matched on sex and birth year. The study included 12 048 cases and 117 895 controls. We estimated rate ratios (RRs) with 95% confidence intervals (CIs). All analyses were adjusted for ambient ultraviolet radiation (UVR). We additionally performed active comparator analyses, and sensitivity analyses by only including new users, distinguishing between exclusive and mixed users, allowing for different latency periods, and subgroup analyses by melanoma subtype and clinical stage. Results: Compared with non-use, we observed a slightly increased melanoma risk in users of diuretics (RR 1.08, CI 1.01-1.15), calcium-channel blockers (RR 1.10, CI 1.04-1.18) and drugs affecting the renin-angiotensin system (RR 1.10, CI 1.04-1.16), but not for beta blockers (RR 0.97, CI 0.92-1.03). We found no heterogeneity of associations by melanoma subtype or clinical stage and no dose-response relationship between the cumulative defined daily doses (DDDs) and melanoma. No interaction was found between cumulative DDDs and ambient UVR. Conclusions: Weak associations, with lack of a dose-response relationship and lack of interactions with ambient UVR, in the DDD analysis in this nationwide study do not support a causal relationship between antihypertensives and melanoma risk.
    Citation
    Ghiasvand R, Berge LAM, Andreassen BK, Stenehjem JS, Heir T, Karlstad Ø, et al. Use of antihypertensive drugs and risk of cutaneous melanoma: a nationwide nested case-control study. Int J Epidemiol. 2022 Nov 22. PubMed PMID: 36413027. Epub 2022/11/23. eng.
    Journal
    International Journal of Epidemiology
    URI
    http://hdl.handle.net/10541/625867
    DOI
    10.1093/ije/dyac223
    PubMed ID
    36413027
    Additional Links
    https://dx.doi.org/10.1093/ije/dyac223
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1093/ije/dyac223
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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