Defining textbook outcome for selective internal radiation therapy of hepatocellular carcinoma: an international expert study
Authors
Gregory, J.Tselikas, L.
Allimant, C.
de Baere, T.
Bargellini, I.
Bell, Jon
Bilbao, J. I.
Bouvier, A.
Chapiro, J.
Chiesa, C.
Decaens, T.
Denys, A.
Duran, R.
Edeline, J.
Garin, E.
Ghelfi, J.
Helmberger, T.
Irani, F.
Lam, M.
Lewandowski, R.
Liu, D.
Loffroy, R.
Madoff, D. C.
Mastier, C.
Salem, R.
Sangro, B.
Sze, D.
Vilgrain, V.
Vouche, M.
Guiu, B.
Ronot, M.
Affiliation
Centre de Recherche de L'Inflammation (CRI), Université Paris Cité, INSERM U1149, Paris, FranceIssue Date
2022
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Background: A textbook outcome (TO) is a composite indicator covering the entire intervention process in order to reflect the "ideal" intervention and be a surrogate for patient important outcomes. Selective internal radiation therapy (SIRT) is a complex multidisciplinary and multistep intervention facing the challenge of standardization. This expert opinion-based study aimed to define a TO for SIRT of hepatocellular carcinoma. Methods: This study involved two steps: (1) the steering committee (4 interventional radiologists) first developed an extensive list of possible relevant items reflecting an optimal SIRT intervention based on a literature review and (2) then conducted an international and multidisciplinary survey which resulted in the final TO. This survey was online, from February to July 2021, and consisted three consecutive rounds with predefined settings. Experts were identified by contacting senior authors of randomized trials, large observational studies, or studies on quality improvement in SIRT. This study was strictly academic. Results: A total of 50 items were included in the first round of the survey. A total of 29/40 experts (73%) responded, including 23 interventional radiologists (79%), three nuclear medicine physicians (10%), two hepatologists, and one oncologist, from 11 countries spanning three continents. The final TO consisted 11 parameters across six domains ("pre-intervention workup," "tumor targeting and dosimetry," "intervention," "post-90Y imaging," "length of hospital stay," and "complications"). Of these, all but one were applied in the institutions of > 80% of experts. Conclusions: This multidimensional indicator is a comprehensive standardization tool, suitable for routine care, clinical round, and research.Citation
Gregory J, Tselikas L, Allimant C, de Baere T, Bargellini I, Bell J, et al. Defining textbook outcome for selective internal radiation therapy of hepatocellular carcinoma: an international expert study. Eur J Nucl Med Mol Imaging. 2022 Oct 25. PubMed PMID: 36282299. Epub 2022/10/26. eng.Journal
European Journal of Nuclear Medicine and Molecular ImagingDOI
10.1007/s00259-022-06002-5PubMed ID
36282299Additional Links
https://dx.doi.org/10.1007/s00259-022-06002-5Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1007/s00259-022-06002-5
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