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    Electrochemotherapy for the treatment of cutaneous squamous cell carcinoma: The INSPECT experience (2008-2020)

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    Authors
    Bertino, G.
    Groselj, A.
    Campana, Luca G
    Kunte, C.
    Schepler, H.
    Gehl, J.
    Muir, T.
    Clover, J. A. P.
    Quaglino, P.
    Kis, E.
    Mascherini, M.
    Bisase, B.
    Pecorari, G.
    Bechara, F.
    Matteucci, P.
    Odili, J.
    Russano, F.
    Orlando, A.
    Pritchard-Jones, R.
    Moir, G.
    Mowatt, David J
    Silvestri, B.
    Seccia, V.
    Saxinger, W.
    de Terlizzi, F.
    Sersa, G.
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    Affiliation
    Department of Otolaryngology Head Neck Surgery, University of Pavia, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy
    Issue Date
    2022
    
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    Abstract
    Introduction: Cutaneous squamous cell carcinoma (cSCC) is a frequent skin cancer with a high risk of recurrence characterized by tumor infiltration and, in advanced cases, a poor prognosis. ECT (electrochemotherapy) is an alternative treatment option for locally advanced or recurrent cSCC that is unsuitable for surgical resection. In this study, we aimed to evaluate the data in the InspECT (International Network for Sharing Practice on ECT) registry of the referral centers and to clarify the indications for the use of ECT as a treatment modality for cSCC. Materials and methods: Patients with primary, recurrent or locally advanced cSCC from 18 European centers were included. They underwent at least one ECT session with bleomycin between February 2008 and November 2020, which was performed following the European Standard Operating Procedures. Results: The analysis included 162 patients (mean age of 80 years; median, 1 lesion/patient). Side effects were mainly local and mild (hyperpigmentation, 11%; ulceration, 11%; suppuration, 4%). The response to treatment per patient was 62% complete and 21% partial. In the multivariate model, intravenous drug administration and small tumor size showed a significant association with a positive outcome (objective response). One-year local progression-free survival was significantly better (p<0.001) in patients with primary tumors (80% (95% C.I. 70%-90%) than in patients with locally advanced disease (49% (95% C.I. 30%-68%). Conclusion: In the present study, ECT showed antitumor activity and a favorable safety profile in patients with complex cSCC for whom there was no widely accepted standard of care. Better results were obtained in primary and small tumors (<3 cm) using intravenous bleomycin administration.
    Citation
    Bertino G, Groselj A, Campana LG, Kunte C, Schepler H, Gehl J, et al. Electrochemotherapy for the treatment of cutaneous squamous cell carcinoma: The INSPECT experience (2008-2020). Frontiers in oncology. 2022;12:951662. PubMed PMID: 36203425. Pubmed Central PMCID: PMC9531998. Epub 2022/10/08. eng.
    Journal
    Frontiers in Oncology
    URI
    http://hdl.handle.net/10541/625706
    DOI
    10.3389/fonc.2022.951662
    PubMed ID
    36203425
    Additional Links
    https://dx.doi.org/10.3389/fonc.2022.951662
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fonc.2022.951662
    Scopus Count
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