The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: Results of the REQUITE study
Authors
van der Weijst, L.Azria, D.
Berkovic, P.
Boisselier, P.
Briers, E.
Bultijnck, R.
Chang-Claude, J.
Choudhury, Ananya
Defraene, G.
Demontois, S.
Elliott, Rebecca M
Ennis, D.
Faivre-Finn, Corinne
Franceschini, M.
Giandini, T.
Giraldo, A.
Gutiérrez-Enríquez, S.
Herskind, C.
Higginson, D. S.
Kerns, S. L.
Johnson, K.
Lambrecht, M.
Lang, P.
Ramos, M.
Rancati, T.
Rimner, A.
Rosenstein, B. S.
De Ruysscher, D.
Salem, Ahmed
Sangalli, C.
Seibold, P.
Sosa Fajardo, P.
Sperk, E.
Stobart, H.
Summersgill, Holly
Surmont, V.
Symonds, P.
Taboada-Valladares, B.
Talbot, C. J.
Vega, A.
Veldeman, L.
Veldwijk, M. R.
Ward, T.
Webb, A.
West, Catharine M L
Lievens, Y.
Affiliation
Department of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumIssue Date
2022
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Background and purpose: To investigate the association between clinician-scored toxicities and patient-reported health-related quality of life (HRQoL), in early-stage (ES-) and locally-advanced (LA-) non-small cell lung cancer (NSCLC) patients receiving loco-regional radiotherapy, included in the international real-world REQUITE study. Materials and methods: Clinicians scored eleven radiotherapy-related toxicities (and baseline symptoms) with the Common Terminology Criteria for Adverse Events version 4. HRQoL was assessed with the European Organization for Research and Treatment of Cancer core HRQoL questionnaire (EORTC-QLQ-C30). Statistical analyses used the mixed-model method; statistical significance was set at p = 0.01. Analyses were performed for baseline and subsequent time points up to 2 years after radiotherapy and per treatment modality, radiotherapy technique and disease stage. Results: Data of 435 patients were analysed. Pre-treatment, overall symptoms, dyspnea, chest wall pain, dysphagia and cough impacted overall HRQoL and specific domains. At subsequent time points, cough and dysphagia were overtaken by pericarditis in affecting HRQoL. Toxicities during concurrent chemo-radiotherapy and 3-dimensional radiotherapy had the most impact on HRQoL. Conversely, toxicities in sequential chemo-radiotherapy and SBRT had limited impact on patients' HRQoL. Stage impacts the correlations: LA-NSCLC patients are more adversely affected by toxicity than ES-NSCLC patients, mimicking the results of radiotherapy technique and treatment modality. Conclusion: Pre-treatment symptoms and acute/late toxicities variously impact HRQoL of ES- and LA-NSCLC patients undergoing different treatment approaches and radiotherapy techniques. Throughout the disease, dyspnea seems crucial in this association, highlighting the additional effect of co-existing comorbidities. Our data call for optimized radiotherapy limiting toxicities that may affect patients' HRQoL.Citation
van der Weijst L, Azria D, Berkovic P, Boisselier P, Briers E, Bultijnck R, et al. The correlation between pre-treatment symptoms, acute and late toxicity and patient-reported health-related quality of life in non-small cell lung cancer patients: Results of the REQUITE study. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2022 Oct 3;176:127-37. PubMed PMID: 36195214. Epub 2022/10/05. eng.Journal
Radiotherapy and OncologyDOI
10.1016/j.radonc.2022.09.020PubMed ID
36195214Additional Links
https://dx.doi.org/10.1016/j.radonc.2022.09.020Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.radonc.2022.09.020
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