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dc.contributor.authorSavage, K. J.
dc.contributor.authorHorwitz, S. M.
dc.contributor.authorAdvani, R.
dc.contributor.authorChristensen, J. H.
dc.contributor.authorDomingo-Domenech, E.
dc.contributor.authorRossi, G.
dc.contributor.authorMorschhauser, F.
dc.contributor.authorAlpdogan, O.
dc.contributor.authorSuh, C.
dc.contributor.authorTobinai, K.
dc.contributor.authorShustov, A.
dc.contributor.authorTrneny, M.
dc.contributor.authorYuen, S.
dc.contributor.authorZinzani, P. L.
dc.contributor.authorTrümper, L.
dc.contributor.authorIlidge, Timothy M
dc.contributor.authorO'Connor, O. A.
dc.contributor.authorPro, B.
dc.contributor.authorMiao, H.
dc.contributor.authorBunn, V.
dc.contributor.authorFenton, K.
dc.contributor.authorFanale, M.
dc.contributor.authorPuhlmann, M.
dc.contributor.authorIyer, S.
dc.date.accessioned2022-10-26T12:58:44Z
dc.date.available2022-10-26T12:58:44Z
dc.date.issued2022en
dc.identifier.citationSavage KJ, Horwitz SM, Advani R, Christensen JH, Domingo-Domenech E, Rossi G, et al. Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2. Blood advances. 2022 Oct 11;6(19):5550-5. PubMed PMID: 35470385. Epub 2022/04/27. eng.en
dc.identifier.pmid35470385en
dc.identifier.doi10.1182/bloodadvances.2020003971en
dc.identifier.urihttp://hdl.handle.net/10541/625676
dc.description.abstractPeripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas, the majority of which have high relapse rates following standard therapy. Despite use of consolidative stem cell transplant (SCT) following frontline therapy, there remains no consensus on its utility. The double-blind randomized phase 3 ECHELON-2 study (#NCT01777152; clinicaltrials.gov) demonstrated improved progression-free survival (PFS) and overall survival with frontline brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP). Herein, we conducted an exploratory subgroups analysis of the impact of consolidative SCT on PFS in patients with previously untreated CD30+ PTCL (ALK- anaplastic large cell lymphoma [ALCL] and non-ALCL) who were in complete response (CR) after frontline treatment with A+CHP or cyclophosphamide, doxorubicin, vincristine, and prednisone. Median PFS follow-up was 47.57 months. The PFS hazard ratio was 0.36, equating to a 64% reduction in the risk of a PFS event in patients who underwent SCT. The median PFS in patients who underwent SCT was not reached, vs 55.66 months in patients who did not undergo SCT. PFS results favored the use of SCT in both ALK- ALCL and non-ALCL subgroups. These data support the consideration of consolidative SCT in patients with CD30+PTCL who achieve CR following treatment with A+CHP.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1182/bloodadvances.2020003971en
dc.titleRole of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2en
dc.typeArticleen
dc.contributor.departmentCentre for Lymphoid Cancer and Division of Medical Oncology, British Columbia Cancer, Vancouver, BC, Canadaen
dc.identifier.journalBlood Advancesen
dc.description.noteen]
refterms.dateFOA2022-11-01T11:28:15Z


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