High rate of Ki-67 increase in entero-pancreatic NET relapses after surgery with curative intent
dc.contributor.author | Merola, E. | |
dc.contributor.author | Perren, A. | |
dc.contributor.author | Rinke, A. | |
dc.contributor.author | Zerbi, A. | |
dc.contributor.author | McNamara, Mairead G | |
dc.contributor.author | Arsenic, R. | |
dc.contributor.author | Fazio, N. | |
dc.contributor.author | de Herder, W. | |
dc.contributor.author | Valle, Juan W | |
dc.contributor.author | Gress, T. M. | |
dc.contributor.author | Wiedenmann, B. | |
dc.contributor.author | Pascher, A. | |
dc.contributor.author | Pavel, M. E. | |
dc.date.accessioned | 2022-10-19T13:13:28Z | |
dc.date.available | 2022-10-19T13:13:28Z | |
dc.date.issued | 2022 | en |
dc.identifier.citation | Merola E, Perren A, Rinke A, Zerbi A, McNamara MG, Arsenic R, et al. High rate of Ki-67 increase in entero-pancreatic NET relapses after surgery with curative intent. Journal of neuroendocrinology. PubMed PMID: WOS:000843551700001. | en |
dc.identifier.doi | 10.1111/jne.13193 | en |
dc.identifier.uri | http://hdl.handle.net/10541/625667 | |
dc.description.abstract | Neuroendocrine neoplasms (NENs) present with advanced disease at diagnosis in upto 28% of cases, precluding the possibility of curative-intent surgery. Histopathologi-cal heterogeneity of this disease can be observed inter-individually as well as intra-individually during disease course. The present study aimed to assess the frequencyof Ki-67 change after radical surgery, in a series of patients with radically resectedentero-pancreatic neuroendocrine tumors (EP-NETs).We present the analysis of a multicenter, retrospective, series of EP-NETs G1–G2recurring after radical resection and with histological re-evaluation at disease recur-rence (DR). The primary endpoint was the description of Ki-67 change at DR com-pared to time of surgery. The secondary endpoint was assessment of recurrence-freesurvival (RFS) rates. In total, 47 patients had a second histological evaluationand could be included in the present study. Median Ki-67 at surgery was 3% (range1–15%) but, at DR, a significant increase in the value was observed (7%, range1–30%;p< .01) and involved 66.0% of cases, with a corresponding increase in tumorgrading in 34.0% (p=.05). Median RFS of the overall population was 40 months, andwas worse when Ki-67 increased at DR vs. stable Ki-67 value (36 vs. 61 months espectively;p=.02). In conclusion, in more than half of the cases with relapse afterradical surgery, a higher proliferative index with a potentially more aggressive poten-tial was observed. Therefore, histological reassessment should be considered on DRbecause tailored therapeutic strategies may be required for these patients. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1111/jne.13193 | en |
dc.title | High rate of Ki-67 increase in entero-pancreatic NET relapses after surgery with curative intent | en |
dc.type | Article | en |
dc.contributor.department | Department of Medicine 1, Division of Endocrinology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany | en |
dc.identifier.journal | Journal of Neuroendocrinology | en |
dc.description.note | en] |