An international comparison of presentation, outcomes and coronet predictive score performance in patients with cancer presenting with COVID-19 across different pandemic waves
Name:
36010932.pdf
Size:
2.033Mb
Format:
PDF
Description:
Identified with Open Access button
Authors
Wysocki, OskarZhou, Cong
Rogado, J.
Huddar, Prerana
Shotton, Rohan
Tivey, Ann
Albiges, L.
Angelakas, Angelos
Arnold, D.
Aung, T.
Banfill, Kathryn
Baxter, M.
Barlesi, F.
Bayle, A.
Besse, B.
Bhogal, T.
Boyce, H.
Britton, Fiona
Calles, A.
Castelo-Branco, L.
Copson, E.
Croitoru, A.
Dani, S. S.
Dickens, E.
Eastlake, L.
Fitzpatrick, Paul
Foulon, S.
Frederiksen, H.
Ganatra, S.
Gennatas, S.
Glenthøj, A.
Gomes, Fabio
Graham, Donna
Hague, Christina
Harrington, K.
Harrison, M.
Horsley, Laura
Hoskins, R.
Hudson, Z.
Jakobsen, L. H.
Joharatnam-Hogan, N.
Khan, S.
Khan, U. T.
Khan, K.
Lewis, Alexandra R
Massard, C.
Maynard, A.
McKenzie, H.
Michielin, O.
Mosenthal, A. C.
Obispo, B.
Palmieri, C.
Patel, R.
Pentheroudakis, G.
Peters, S.
Rieger-Christ, K.
Robinson, T.
Romano, E.
Rowe, M.
Sekacheva, M.
Sheehan, R.
Stockdale, A.
Thomas, A.
Turtle, L.
Viñal, D.
Weaver, Jamie M
Williams, S.
Wilson, C.
Dive, Caroline
Landers, Donal
Cooksley, Timothy J
Freitas, Andre
Armstrong, Anne C
Lee, Rebecca J
Affiliation
Department of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UKIssue Date
2022
Metadata
Show full item recordAbstract
Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. The majority of patients were vaccinated in wave 4, and 94% were treated with steroids if they required oxygen. The stages of cancer and the median ages of patients significantly differed, but features associated with worse COVID-19 outcomes remained predictive and did not differ between waves. The CORONET tool performed well in all waves, with scores in an area under the curve (AUC) of >0.72. We concluded that patients with cancer who present to hospital with COVID-19 have similar features of severity, which remain discriminatory despite differences in variants and vaccination status. Survival improved following the first wave of the pandemic, which may be associated with vaccination and the increased steroid use in those patients requiring oxygen. The CORONET model demonstrated good performance, independent of the SARS-CoV-2 variants.Citation
Wysocki O, Zhou C, Rogado J, Huddar P, Shotton R, Tivey A, et al. An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves. Cancers (Basel). 2022 Aug 16;14(16). PubMed PMID: 36010932. Pubmed Central PMCID: PMC9406013. Epub 2022/08/27. eng.Journal
CancersDOI
10.3390/cancers14163931PubMed ID
36010932Additional Links
https://dx.doi.org/10.3390/cancers14163931Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/cancers14163931
Scopus Count
Collections
Related articles
- Establishment of CORONET, COVID-19 Risk in Oncology Evaluation Tool, to Identify Patients With Cancer at Low Versus High Risk of Severe Complications of COVID-19 Disease On Presentation to Hospital.
- Authors: Lee RJ, Wysocki O, Zhou C, Shotton R, Tivey A, Lever L, Woodcock J, Albiges L, Angelakas A, Arnold D, Aung T, Banfill K, Baxter M, Barlesi F, Bayle A, Besse B, Bhogal T, Boyce H, Britton F, Calles A, Castelo-Branco L, Copson E, Croitoru AE, Dani SS, Dickens E, Eastlake L, Fitzpatrick P, Foulon S, Frederiksen H, Frost H, Ganatra S, Gennatas S, Glenthøj A, Gomes F, Graham DM, Hague C, Harrington K, Harrison M, Horsley L, Hoskins R, Huddar P, Hudson Z, Jakobsen LH, Joharatnam-Hogan N, Khan S, Khan UT, Khan K, Massard C, Maynard A, McKenzie H, Michielin O, Mosenthal AC, Obispo B, Patel R, Pentheroudakis G, Peters S, Rieger-Christ K, Robinson T, Rogado J, Romano E, Rowe M, Sekacheva M, Sheehan R, Stevenson J, Stockdale A, Thomas A, Turtle L, Viñal D, Weaver J, Williams S, Wilson C, Palmieri C, Landers D, Cooksley T, ESMO Co-Care, Dive C, Freitas A, Armstrong AC
- Issue date: 2022 May
- Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers.
- Authors: Ali AM, Tofiq AM, Rostam HM, Ali KM, Tawfeeq HM
- Issue date: 2022 Dec
- Cutaneous manifestations of SARS-CoV-2 infection during the Delta and Omicron waves in 348 691 UK users of the UK ZOE COVID Study app.
- Authors: Visconti A, Murray B, Rossi N, Wolf J, Ourselin S, Spector TD, Freeman EE, Bataille V, Falchi M
- Issue date: 2022 Dec
- Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study.
- Authors: Pinato DJ, Aguilar-Company J, Ferrante D, Hanbury G, Bower M, Salazar R, Mirallas O, Sureda A, Plaja A, Cucurull M, Mesia R, Townsend S, Jackson A, Dalla Pria A, Newsom-Davis T, Handford J, Sita-Lumsden A, Apthorp E, Vincenzi B, Bertuzzi A, Brunet J, Lambertini M, Maluquer C, Pedrazzoli P, Biello F, Sinclair A, Bawany S, Khalique S, Rossi S, Rogers L, Murphy C, Belessiotis K, Carmona-García MC, Sharkey R, García-Illescas D, Rizzo G, Perachino M, Saoudi-Gonzalez N, Doonga K, Fox L, Roldán E, Gaidano G, Ruiz-Camps I, Bruna R, Patriarca A, Martinez-Vila C, Cantini L, Zambelli A, Giusti R, Mazzoni F, Caliman E, Santoro A, Grosso F, Parisi A, Queirolo P, Aujayeb A, Rimassa L, Prat A, Tucci M, Libertini M, Grisanti S, Mukherjee U, Diamantis N, Fusco V, Generali D, Provenzano S, Gennari A, Tabernero J, Cortellini A, OnCovid study group
- Issue date: 2022 Jul
- The impact of shifting demographics, variants of concern and vaccination on outcomes during the first 3 COVID-19 waves in Alberta and Ontario: a retrospective cohort study.
- Authors: McAlister FA, Nabipoor M, Chu A, Lee DS, Saxinger L, Bakal JA, CORONA Collaboration
- Issue date: 2022 Apr-Jun