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    A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE)

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    Authors
    Underwood, Tracey
    McNamara, A. L.
    Appelt, A.
    Haviland, J. S.
    Singers Sørensen, B.
    Troost, E. G. C.
    Affiliation
    Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
    Issue Date
    2022
    
    Metadata
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    Abstract
    Recently, a number of clinical studies have explored links between possible Relative Biological Effectiveness (RBE) elevations and patient toxicities and/or image changes following proton therapy. Our objective was to perform a systematic review of such studies. We applied a "Problem [RBE], Intervention [Protons], Population [Patients], Outcome [Side effect]" search strategy to the PubMed database. From our search, we retrieved studies which: (a) performed novel voxel-wise analyses of patient effects versus physical dose and LET (n = 13), and (b) compared image changes between proton and photon cohorts with regard to proton RBE (n = 9). For each retrieved study, we extracted data regarding: primary tumour type; size of patient cohort; type of image change studied; image-registration method (deformable or rigid); LET calculation method, and statistical methodology. We compared and contrasted their methods in order to discuss the weight of clinical evidence for variable proton RBE. We concluded that clinical evidence for variable proton RBE remains statistically weak at present. Our principal recommendation is that proton centres and clinical trial teams collaborate to standardize follow-up protocols and statistical analysis methods, so that larger patient cohorts can ultimately be considered for RBE analyses.
    Citation
    Sa Underwood T, McNamara AL, Appelt A, Haviland JS, Singers Sørensen B, Troost EGC. A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE). Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2022 Aug 18. PubMed PMID: 35988776. Epub 2022/08/22. eng.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/625580
    DOI
    10.1016/j.radonc.2022.08.014
    PubMed ID
    35988776
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2022.08.014
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2022.08.014
    Scopus Count
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    All Paterson Institute for Cancer Research

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