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    Changes in body weight and serum cholesterol after heart transplant in relation to ventricular assist device implantation

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    Authors
    Miura, K.
    Yu, R.
    Entwistle, T. R.
    McKenzie, S. C.
    Green, Adèle C
    Affiliation
    Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Weight gain is common after implantation of a ventricular assist device (VAD) prior to heart transplantation, but post-transplant changes in weight and also in blood lipids in those with VAD is virtually unknown. This study aimed to determine the influence of pre-transplant VAD implantation on body weight, blood cholesterol and triglyceride levels in Australian adult heart transplant recipients (HTRs), 1990-2017, from time of transplantation to 36 months post-transplantation. Information on VAD implantation, weight and blood lipids was collected for HTRs from medical records. Changes in weight and blood lipids from post-transplant to 12-, 24 and 36 months later, were assessed by VAD status using linear mixed-effects models. Of 236 heart transplant recipients, 48 (20%) had VAD implants. HTRs irrespective of VAD status, tended to increase their mean weight (p < 0.001) over 36 months (VAD implant: 76.9-84.4 kg; no VAD: 81.3-88.2 kg). Patients with VAD tended to have lower mean blood lipids but experienced increases similar to those with no VAD, from baseline to 36 months (cholesterol: VAD: 4.24-4.66 mmol/l; no VAD: 4.73-4.88 mmol/l; p = 0.05; triglycerides: VAD 1.59-1.63 mmol/l; no VAD 1.85-2.22 mmol/l; p = 0.09). We conclude that HTRs in general experience weight gain and lipid increases in the first 36 months after transplantation, regardless of prior VAD implantation.
    Citation
    Miura K, Yu R, Entwistle TR, McKenzie SC, Green AC. Changes in body weight and serum cholesterol after heart transplant in relation to ventricular assist device implantation. The International journal of artificial organs. 2022 Aug 18:3913988221118942. PubMed PMID: 35982584. Epub 2022/08/20. eng.
    Journal
    International Journal of Artificial Organs
    URI
    http://hdl.handle.net/10541/625575
    DOI
    10.1177/03913988221118942
    PubMed ID
    35982584
    Additional Links
    https://dx.doi.org/10.1177/03913988221118942
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1177/03913988221118942
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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