Changes in body weight and serum cholesterol after heart transplant in relation to ventricular assist device implantation
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Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, AustraliaIssue Date
2022
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Weight gain is common after implantation of a ventricular assist device (VAD) prior to heart transplantation, but post-transplant changes in weight and also in blood lipids in those with VAD is virtually unknown. This study aimed to determine the influence of pre-transplant VAD implantation on body weight, blood cholesterol and triglyceride levels in Australian adult heart transplant recipients (HTRs), 1990-2017, from time of transplantation to 36 months post-transplantation. Information on VAD implantation, weight and blood lipids was collected for HTRs from medical records. Changes in weight and blood lipids from post-transplant to 12-, 24 and 36 months later, were assessed by VAD status using linear mixed-effects models. Of 236 heart transplant recipients, 48 (20%) had VAD implants. HTRs irrespective of VAD status, tended to increase their mean weight (p < 0.001) over 36 months (VAD implant: 76.9-84.4 kg; no VAD: 81.3-88.2 kg). Patients with VAD tended to have lower mean blood lipids but experienced increases similar to those with no VAD, from baseline to 36 months (cholesterol: VAD: 4.24-4.66 mmol/l; no VAD: 4.73-4.88 mmol/l; p = 0.05; triglycerides: VAD 1.59-1.63 mmol/l; no VAD 1.85-2.22 mmol/l; p = 0.09). We conclude that HTRs in general experience weight gain and lipid increases in the first 36 months after transplantation, regardless of prior VAD implantation.Citation
Miura K, Yu R, Entwistle TR, McKenzie SC, Green AC. Changes in body weight and serum cholesterol after heart transplant in relation to ventricular assist device implantation. The International journal of artificial organs. 2022 Aug 18:3913988221118942. PubMed PMID: 35982584. Epub 2022/08/20. eng.Journal
International Journal of Artificial OrgansDOI
10.1177/03913988221118942PubMed ID
35982584Additional Links
https://dx.doi.org/10.1177/03913988221118942Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1177/03913988221118942
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