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    Palliative radiotherapy in cancers of female genital tract: Outcomes and prognostic factors

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    Authors
    Harsha Kombathula, Sri
    Cree, Anthea
    Joshi, P. V.
    Akturk, Nesrin
    Barraclough, Lisa H
    Haslett, Kate
    Choudhury, Ananya
    Hoskin, Peter J
    Affiliation
    The Christie NHS Foundation Trust, Clinical Oncology, Manchester, United Kingdom
    Issue Date
    2022
    
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    Abstract
    Background and purpose: Metastatic and incurable cancers of the gynaecological tract (FGTC) represent a major global health burden. Systemic treatment has modest efficacy and radiotherapy is often used for local symptoms. This study combines experience from two large UK centres in palliative radiotherapy for gynaecological cancers. Materials and methods: Pooled data from two major centres was analysed. Advanced FGTC patients who received at least one fraction of palliative radiotherapy to the pelvis between 2013 and 2018 were included. Data collected included demographic and tumour details, radiotherapy dose fractionation and details of previous and subsequent treatment. Response was defined in terms of toxicity, symptomatic response and survival. Comorbidities were recorded using a modified ACE 27 score which is adjusted for the presence of uncontrolled FGTC in all the patients. Results: A total of 184 patients were included for treatment response and toxicity; survival data was available for 165 patients. Subjective response in pre-radiotherapy symptoms was documented in 80.4%. Grade 3 or worse gastrointestinal, urinary and other (vomiting, fatigue, pain) toxicity incidence was 2.2%, 3.8%, and 2.7% respectively. No statistically significant correlation between the prescribed EQD210 and symptom control or toxicity was seen. 1 year overall survival was 25.1% (median 5.9 months). Absent distant metastases, completion of the intended course of radiotherapy, response to radiotherapy, and receipt of further lines of treatment were independent prognostic factors. Conclusion: Palliative radiotherapy is effective for symptoms of advanced FGTC with low toxicity. The absence of a dose response argues for short low dose palliative radiotherapy schedules to be used.
    Citation
    Harsha Kombathula S, Cree A, Joshi PV, Akturk N, Barraclough LH, Haslett K, et al. Palliative radiotherapy in cancers of female genital tract: Outcomes and prognostic factors. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2022 Aug 11. PubMed PMID: 35964765. Epub 2022/08/15. eng.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/625570
    DOI
    10.1016/j.radonc.2022.07.023
    PubMed ID
    35964765
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2022.07.023
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2022.07.023
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