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    Interplay of developmental hippo-notch signaling pathways with the DNA damage response in prostate cancer

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    Authors
    Mourkioti, I.
    Angelopoulou, A.
    Belogiannis, K.
    Lagopati, N.
    Potamianos, S.
    Kyrodimos, E.
    Gorgoulis, Vassilis G
    Papaspyropoulos, A.
    Affiliation
    Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 11527 Athens, Greece
    Issue Date
    2022
    
    Metadata
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    Abstract
    Prostate cancer belongs in the class of hormone-dependent cancers, representing a major cause of cancer incidence in men worldwide. Since upon disease onset almost all prostate cancers are androgen-dependent and require active androgen receptor (AR) signaling for their survival, the primary treatment approach has for decades relied on inhibition of the AR pathway via androgen deprivation therapy (ADT). However, following this line of treatment, cancer cell pools often become resistant to therapy, contributing to disease progression towards the significantly more aggressive castration-resistant prostate cancer (CRPC) form, characterized by poor prognosis. It is, therefore, of critical importance to elucidate the molecular mechanisms and signaling pathways underlying the progression of early-stage prostate cancer towards CRPC. In this review, we aim to shed light on the role of major signaling pathways including the DNA damage response (DDR) and the developmental Hippo and Notch pathways in prostate tumorigenesis. We recapitulate key evidence demonstrating the crosstalk of those pathways as well as with pivotal prostate cancer-related 'hubs' such as AR signaling, and evaluate the clinical impact of those interactions. Moreover, we attempt to identify molecules of the complex DDR-Hippo-Notch interplay comprising potentially novel therapeutic targets in the battle against prostate tumorigenesis.
    Citation
    Mourkioti I, Angelopoulou A, Belogiannis K, Lagopati N, Potamianos S, Kyrodimos E, et al. Interplay of Developmental Hippo-Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer. Cells. 2022 Aug 7;11(15). PubMed PMID: 35954292. Pubmed Central PMCID: PMC9367915. Epub 2022/08/13. eng.
    Journal
    Cells
    URI
    http://hdl.handle.net/10541/625564
    DOI
    10.3390/cells11152449
    PubMed ID
    35954292
    Additional Links
    https://dx.doi.org/10.3390/cells11152449
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cells11152449
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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