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    European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL)

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    Authors
    Hoang-Xuan, K.
    Deckert, M.
    Ferreri, A. J. M.
    Furtner, J.
    Gallego Perez-Larraya, J.
    Henriksson, R.
    Hottinger, A. F.
    Kasenda, B.
    Lefranc, F.
    Lossos, A.
    McBain, Catherine A
    Preusser, M.
    Roth, P.
    Rudà, R.
    Schlegel, U.
    Soffietti, R.
    Soussain, C.
    Taphoorn, M. J. B.
    Touitou, V.
    Weller, M.
    Bromberg, J. E. C.
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    Affiliation
    APHP, Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière; Sorbonne Université; IHU; ICM. Paris, France.
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the limited number of controlled studies available. In 2021, given recent advances and publication of practice-changing randomised trials, the European Association of Neuro-Oncology (EANO) created a multidisciplinary task force to update the previously published evidence-based guidelines for immunocompetent adult patients with PCNSL and added a section on immunosuppressed patients. The guideline provides consensus considerations and recommendations for treatment of PCNSL, including intraocular manifestations and specific management of elderly . The main changes from the previous guideline include strenghtened evidence for the consolidation with ASCT in first-line treatment, prospectively assessed chemotherapy combinations for both young and elderly patients, clarification of the role of rituximab even though the data remain inconclusive, of the role of new agents, and the incorporation of immunosuppressed patients and primary ocular lymphoma. The guideline should aid the clinicians in everyday practice and decision making and serve as a basis for future research in the field.
    Citation
    Hoang-Xuan K, Deckert M, Ferreri AJM, Furtner J, Gallego Perez-Larraya J, Henriksson R, et al. European Association of Neuro-Oncology (EANO) Guidelines for Treatment of Primary Central Nervous System lymphoma (PCNSL). Neuro-oncology. 2022 Aug 12. PubMed PMID: 35953526. Epub 2022/08/12. eng.
    Journal
    Neuro Oncology
    URI
    http://hdl.handle.net/10541/625563
    DOI
    10.1093/neuonc/noac196
    PubMed ID
    35953526
    Additional Links
    https://dx.doi.org/10.1093/neuonc/noac196
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1093/neuonc/noac196
    Scopus Count
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