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    Untangling the tumorigenic role of homotrimeric collagen I

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    Authors
    Jørgensen, Claus
    Affiliation
    Systems Oncology, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Manchester, SK10 4TG, UK.
    Issue Date
    2022
    
    Metadata
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    Abstract
    Pancreatic ductal adenocarcinoma is characterized by a complex microenvironment. In this issue of Cancer Cell, Chen and colleagues define an oncogenic role of tumor-cell-produced collagen I homotrimers, wherein tumor development is promoted by integrin α3/β1-dependent activation of tumor cell signaling and modulation of tumor microbiome and immunity.
    Citation
    Jørgensen C. Untangling the tumorigenic role of homotrimeric collagen I. Cancer cell. 2022 Aug 8;40(8):802-4. PubMed PMID: 35944498. Epub 2022/08/10. eng.
    Journal
    Cancer Cell
    URI
    http://hdl.handle.net/10541/625558
    DOI
    10.1016/j.ccell.2022.07.007
    PubMed ID
    35944498
    Additional Links
    https://dx.doi.org/10.1016/j.ccell.2022.07.007
    Type
    Other
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ccell.2022.07.007
    Scopus Count
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    All Paterson Institute for Cancer Research

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