Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter
dc.contributor.author | Exarchou, K. | |
dc.contributor.author | Hu, H. | |
dc.contributor.author | Stephens, N. A. | |
dc.contributor.author | Moore, A. R. | |
dc.contributor.author | Kelly, M. | |
dc.contributor.author | Lamarca, Angela | |
dc.contributor.author | Mansoor, Was | |
dc.contributor.author | Hubner, Richard A | |
dc.contributor.author | McNamara, Mairead G | |
dc.contributor.author | Smart, H. | |
dc.contributor.author | Howes, N. R. | |
dc.contributor.author | Valle, Juan W | |
dc.contributor.author | Pritchard, D. M. | |
dc.date.accessioned | 2022-08-31T11:38:30Z | |
dc.date.available | 2022-08-31T11:38:30Z | |
dc.date.issued | 2022 | en |
dc.identifier.citation | Exarchou K, Hu H, Stephens NA, Moore AR, Kelly M, Lamarca A, et al. Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter. Endocrine. 2022 Jul 27. PubMed PMID: 35895180. Epub 2022/07/28. eng. | en |
dc.identifier.pmid | 35895180 | en |
dc.identifier.doi | 10.1007/s12020-022-03143-3 | en |
dc.identifier.uri | http://hdl.handle.net/10541/625540 | |
dc.description.abstract | Purpose: Type I gastric neuroendocrine neoplasms (g-NENs) have a low risk of metastasis and a generally favourable prognosis. Patients with small type I g-NENs (≤10 mm) frequently require no treatment, whereas those with larger polyps usually undergo resection. We evaluated the safety and outcomes of endoscopic surveillance after no initial treatment in selected patients with type I g-NENs. Methods: Retrospective analysis of type I g-NEN patients across two European Neuroendocrine Tumour Society Centers of Excellence 2003-2019. Results: Following initial assessment, 87 of 115 patients with type I g-NEN (75 with polyps ≤10 mm) received no initial treatment and underwent endoscopic surveillance. 79/87 (91%) demonstrated no clinically meaningful change in tumour size or grade over a median 62 month follow up. Only two patients developed NEN progression that required a change in management and two other patients developed gastric adenocarcinoma/high grade dysplasia; all four initially had ≥11 mm g-NENs. Conclusions: Patients with ≤10 mm type I g-NENs were unlikely to develop clinically significant tumour progression and in most cases, resection was not needed. The endoscopic surveillance interval could therefore potentially be safely increased to every 2-3 years in such patients. However, lifelong surveillance is still advocated due to the additional risk of developing gastric adenocarcinoma. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1007/s12020-022-03143-3 | en |
dc.title | Endoscopic surveillance alone is feasible and safe in type I gastric neuroendocrine neoplasms less than 10 mm in diameter | en |
dc.type | Article | en |
dc.contributor.department | Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK | en |
dc.identifier.journal | Endocrine | en |
dc.description.note | en] | |
refterms.dateFOA | 2022-08-31T12:13:00Z |