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    3D Bioprinting: an enabling technology to understand melanoma

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    Authors
    Fernandes, S.
    Vyas, C.
    Lim, P.
    Pereira, R. F.
    Virós, Amaya
    Bártolo, P.
    Affiliation
    Department of Mechanical, Aerospace and Civil Engineering, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Melanoma is a potentially fatal cancer with rising incidence over the last 50 years, associated with enhanced sun exposure and ultraviolet radiation. Its incidence is highest in people of European descent and the ageing population. There are multiple clinical and epidemiological variables affecting melanoma incidence and mortality, such as sex, ethnicity, UV exposure, anatomic site, and age. Although survival has improved in recent years due to advances in targeted and immunotherapies, new understanding of melanoma biology and disease progression is vital to improving clinical outcomes. Efforts to develop three-dimensional human skin equivalent models using biofabrication techniques, such as bioprinting, promise to deliver a better understanding of the complexity of melanoma and associated risk factors. These 3D skin models can be used as a platform for patient specific models and testing therapeutics.
    Citation
    Fernandes S, Vyas C, Lim P, Pereira RF, Virós A, Bártolo P. 3D Bioprinting: An Enabling Technology to Understand Melanoma. Cancers (Basel). 2022 Jul 20;14(14). PubMed PMID: 35884596. Pubmed Central PMCID: PMC9318274. Epub 2022/07/28. eng.
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/625538
    DOI
    10.3390/cancers14143535
    PubMed ID
    35884596
    Additional Links
    https://dx.doi.org/10.3390/cancers14143535
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers14143535
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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