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    Malignant bowel obstruction in advanced ovarian cancer: A retrospective analysis of patients supported with parenteral nutrition

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    Authors
    Wight, Rebecca
    Murphy, A. D.
    Bower, J.
    Morgan, Robert David
    Flanagan, L.
    Maycock, S.
    Lal, S.
    Teubner, A.
    Abraham, A.
    Mitchell, Claire L
    Hasan, Jurjees
    Jayson, Gordon C
    Clamp, Andrew R
    Salih, Zena
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    Affiliation
    Medical Oncology Dept., The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2022
    
    Metadata
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    Abstract
    Background: Malignant bowel obstruction (MBO) is common in advanced ovarian cancer (AOC). Treatment options are limited as majority of cases present with widespread, multilevel peritoneal dissemination and platinum-resistant disease. The benefit of Parenteral Nutrition (PN) in MBO is debated, given the limited overall survival (OS) of this patient group. Aim: to identify which clinical features correlate with improved survival in AOC and MBO, to support clinical decision-making. Methods: Retrospective review of patients admitted with MBO between April 2019 and October 2021 to a single tertiary cancer centre. Those with AOC established on PN with the aim to discharge home on PN were included. Univariate analysis for survival after commencing PN was performed using log-rank test. Results: 103 patients with MBO were identified with 33 patients excluded (PN not initiated, 15; PN withdrawn: covid service constraint, 5, acute medical event, 13). 70 patients were successfully established on PN and 49 discharged on PN; 16 patients clinically deteriorated; 5 returned to enteral diet. Median OS of patients that did not receive PN was 19 days, PN stopped due to general deterioration 39 days and 100 days (range 18-807) for those established on PN (p<0.0001). Clinical features asso ciated with improved OS: no prior systemic therapy (p¼0.0067), platinum sensitivity (p¼0.043), ECOG performance status (PS) 1 vs 2-3 (p¼0.004), falling modified Glas gow Prognostic Score (mGPS) during admission (p¼0.0027). In the treatment naïve group, chemotherapy resolved MBO in 6/9 cases. In the pre-treated group, 60% of patients received subsequent chemotherapy (median duration 8 weeks), with early cessation due to toxicity and no clinical benefit. Only 1 patient achieved resolution of MBO on chemotherapy. Conclusions: PN may improve survival of patients with AOC in MBO. ECOG PS, platinum sensitivity and mGPS trend may be useful to select patients for PN. In those presenting with MBO at AOC diagnosis, PN can enable safe delivery of chemotherapy, which usually will resolve MBO. In pre-treated patients, PN is a life-long commitment and chemotherapy is largely ineffective in resolving MBO. Further research should focus on quality of life in patients receiving PN.
    Citation
    Wight RKK, Murphy AD, Bower J, Morgan RD, Flanagan L, Maycock S, et al. Malignant bowel obstruction in advanced ovarian cancer: A retrospective analysis of patients supported with parenteral nutrition. Annals of Oncology. 2022 Jun;33:S400-S. PubMed PMID: WOS:000814982500044.
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/625535
    DOI
    10.1016/j.annonc.2022.04.061
    Additional Links
    https://dx.doi.org/10.1016/j.annonc.2022.04.061
    Type
    Meetings and Proceedings
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.annonc.2022.04.061
    Scopus Count
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