• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Identifying the priority challenges of facilitating national proton beam therapy clinical trials

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Davies, Lucy
    Parker, Jacqui
    Amaro, P. T.
    Whiteside, Lee
    Eccles, Cynthia L
    Bailey, Rachael
    Falk, Sally
    Webb, Julie
    McHugh, Louise
    Affiliation
    The Christie NHS Foundation Trust, Radiotherapy, Manchester
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Purpose or Objective Since the UK’s first NHS high-energy proton beam therapy (PBT) centre became operational in 2018, a significant proportion of patients referred for treatment have been enrolled in clinical trials. External patient referrals from healthcare organisations across the whole of the UK has highlighted a need for greater research governance and the streamlining of complex PBT data transfer procedures compared to existing local radiotherapy trial processes. This work reports on the process of identifying the priority challenges with a view to improving the proton trial pathway using an evaluative methodology, the nominal group technique (NGT). Materials and Methods To identify the key issues surrounding the practical implementation of PBT clinical trials, the facilitation of patient PBT trial pathways and transfer of radiotherapy trial data, a modified NGT approach was used. Briefly, the 6-step modified NGT includes the presentation of a question to a group followed by silent, round robin, discussion, scoring and data combining phases (Table 1). A panel was convened comprising five research radiographers with experience facilitating patient pathways and reporting radiotherapy data in adherence with PBT trials. Participants were presented with the question: “What are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?” The results of the NGT were used to make recommendations informing local operational policy processes, which may provide guidance for new PBT centre’s as they become clinically operational. Results A total of 59 challenges were identified after combining lists generated by each panel member. Responses were clarified, refined through discussion and duplications were eliminated, resulting in 14 challenges progressing to the scoring and ranking phase. Participants individually selected 5 of the 14 challenges that they deemed most pertinent and distributed a score (out of a possible 10 points) across their 5 chosen challenges. Individual points were combined when the group reconvened generating a ranked, weighted order of responses from the cohort to the initial question. Two priority challenges scored the highest, with every participant allocating points to these issues. These were: 1) a lack of initial understanding of responsibilities of teams and who the relevant stakeholders were, and 2) the nature of the national PBT service requiring the provision of shared care across numerous multi-disciplinary teams and multiple sites, with each organisation having their own working processes. Conclusion This work has identified the need to develop shared protocols identifying and clarifying responsibilities of multiple stakeholders to streamline PBT trial processes, promote understanding of the respective responsibilities, and improve communication between centres referring patients for PBT and PBT trials. The NGT is an effective tool for reaching consensus and identifying context-specific priority areas for quality improvement.
    Citation
    Davies L, Parker J, Amaro PT, Whiteside L, Eccles C, Bailey R, et al. Identifying the priority challenges of facilitating national proton beam therapy clinical trials. Radiotherapy and Oncology. 2022 May;170:S109-S. PubMed PMID: WOS:000806759200107.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/625470
    Type
    Meetings and Proceedings
    Language
    en
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.