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    The EBMT immune effector cell nursing guidelines on CAR-T therapy: a framework for patient care and managing common toxicities

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    Authors
    Ellard, R.
    Kenyon, M.
    Hutt, D.
    Aerts, E.
    de Ruijter, M.
    Chabannon, C.
    Mohty, M.
    Montoto, S.
    Wallhult, E.
    Murray, John
    Affiliation
    The Royal Marsden Hospitals NHS Foundation Trust, Fulham Road, London, SW3 6JJ UK
    Issue Date
    2022
    
    Metadata
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    Abstract
    Chimeric antigen receptor T-cell (CAR T) therapy is a new and rapidly developing field. Centers across the world are gaining more experience using these innovative anti-cancer treatments, transitioning from the 'bench' to the 'bedside', giving benefit to an increasing number of patients. For those with some refractory hematological malignancies, CAR-T may offer a treatment option that was not available a few years ago. CAR-T therapy is an immune effector cell and precision/personalized medicine treatment which is tailored to the individual patient and associated with a variety of unique adverse events and toxicities that necessitate specialist nursing/medical vigilance in an appropriate clinical setting. Subtle unrecognized signs and symptoms can result in rapid deterioration and, possibly, life threatening cardiorespiratory and/or neurological sequelae. These guidelines have been prepared for nurses working in cellular therapy in inpatient, outpatient and ambulatory settings. Many nurses will encounter cellular therapy recipients indirectly, during the referral process, following discharge, and when patients are repatriated back to local centers. The aim of these guidelines is to provide all nurses with a practice framework to enable recognition, monitoring and grading of CAR-T therapy-associated toxicities, and to support and nurse these highly complex patients with confidence. They have been developed under the auspices of several bodies of the European society for Blood and Marrow Transplantation (EBMT), by experienced health professionals, and will be a valuable resource to all practitioners working in cellular therapy.
    Citation
    Ellard R, Kenyon M, Hutt D, Aerts E, de Ruijter M, Chabannon C, et al. The EBMT Immune Effector Cell Nursing Guidelines on CAR-T Therapy: A Framework for Patient Care and Managing Common Toxicities. Clinical hematology international. 2022 Jul 8:1-14. PubMed PMID: 35821976. Pubmed Central PMCID: PMC9263804. Epub 2022/07/14. eng.
    Journal
    Clinical Hematology International
    URI
    http://hdl.handle.net/10541/625426
    DOI
    10.1007/s44228-022-00004-8
    PubMed ID
    35821976
    Additional Links
    https://dx.doi.org/10.1007/s44228-022-00004-8
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s44228-022-00004-8
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