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dc.contributor.authorThakkar, M. K.
dc.contributor.authorLee, J.
dc.contributor.authorMeyer, Stefan
dc.contributor.authorChang, V. Y.
dc.date.accessioned2022-08-17T09:45:33Z
dc.date.available2022-08-17T09:45:33Z
dc.date.issued2022en
dc.identifier.citationThakkar MK, Lee J, Meyer S, Chang VY. RecQ Helicase Somatic Alterations in Cancer. Frontiers in molecular biosciences. 2022;9:887758. PubMed PMID: 35782872. Pubmed Central PMCID: PMC9240438. Epub 2022/07/06. eng.en
dc.identifier.pmid35782872en
dc.identifier.doi10.3389/fmolb.2022.887758en
dc.identifier.urihttp://hdl.handle.net/10541/625412
dc.description.abstractNamed the "caretakers" of the genome, RecQ helicases function in several pathways to maintain genomic stability and repair DNA. This highly conserved family of enzymes consist of five different proteins in humans: RECQL1, BLM, WRN, RECQL4, and RECQL5. Biallelic germline mutations in BLM, WRN, and RECQL4 have been linked to rare cancer-predisposing syndromes. Emerging research has also implicated somatic alterations in RecQ helicases in a variety of cancers, including hematological malignancies, breast cancer, osteosarcoma, amongst others. These alterations in RecQ helicases, particularly overexpression, may lead to increased resistance of cancer cells to conventional chemotherapy. Downregulation of these proteins may allow for increased sensitivity to chemotherapy, and, therefore, may be important therapeutic targets. Here we provide a comprehensive review of our current understanding of the role of RecQ DNA helicases in cancer and discuss the potential therapeutic opportunities in targeting these helicases.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3389/fmolb.2022.887758en
dc.titleRecQ helicase somatic alterations in canceren
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of California, Los Angeles, Los Angeles, CAen
dc.identifier.journalFrontiers in Molecular Biosciencesen
dc.description.noteen]
refterms.dateFOA2022-08-22T10:57:00Z


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