• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    RecQ helicase somatic alterations in cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    35782872.pdf
    Size:
    1.309Mb
    Format:
    PDF
    Description:
    Identified with Open Access button
    Download
    Authors
    Thakkar, M. K.
    Lee, J.
    Meyer, Stefan
    Chang, V. Y.
    Affiliation
    Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of California, Los Angeles, Los Angeles, CA
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Named the "caretakers" of the genome, RecQ helicases function in several pathways to maintain genomic stability and repair DNA. This highly conserved family of enzymes consist of five different proteins in humans: RECQL1, BLM, WRN, RECQL4, and RECQL5. Biallelic germline mutations in BLM, WRN, and RECQL4 have been linked to rare cancer-predisposing syndromes. Emerging research has also implicated somatic alterations in RecQ helicases in a variety of cancers, including hematological malignancies, breast cancer, osteosarcoma, amongst others. These alterations in RecQ helicases, particularly overexpression, may lead to increased resistance of cancer cells to conventional chemotherapy. Downregulation of these proteins may allow for increased sensitivity to chemotherapy, and, therefore, may be important therapeutic targets. Here we provide a comprehensive review of our current understanding of the role of RecQ DNA helicases in cancer and discuss the potential therapeutic opportunities in targeting these helicases.
    Citation
    Thakkar MK, Lee J, Meyer S, Chang VY. RecQ Helicase Somatic Alterations in Cancer. Frontiers in molecular biosciences. 2022;9:887758. PubMed PMID: 35782872. Pubmed Central PMCID: PMC9240438. Epub 2022/07/06. eng.
    Journal
    Frontiers in Molecular Biosciences
    URI
    http://hdl.handle.net/10541/625412
    DOI
    10.3389/fmolb.2022.887758
    PubMed ID
    35782872
    Additional Links
    https://dx.doi.org/10.3389/fmolb.2022.887758
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmolb.2022.887758
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Human RecQ Helicases in DNA Double-Strand Break Repair.
    • Authors: Lu H, Davis AJ
    • Issue date: 2021
    • Human RecQ helicases in DNA repair, recombination, and replication.
    • Authors: Croteau DL, Popuri V, Opresko PL, Bohr VA
    • Issue date: 2014
    • RECQL4 in genomic instability and aging.
    • Authors: Croteau DL, Singh DK, Hoh Ferrarelli L, Lu H, Bohr VA
    • Issue date: 2012 Dec
    • Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer.
    • Authors: Maity J, Horibata S, Zurcher G, Lee JM
    • Issue date: 2022 Feb 26
    • RECQL5 at the Intersection of Replication and Transcription.
    • Authors: Hamadeh Z, Lansdorp P
    • Issue date: 2020
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.