Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer
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Tumour Suppressors Group, Cancer Research United Kingdom (UK) Manchester Institute, The University of Manchester, MacclesfieldIssue Date
2021
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Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.Citation
von Grabowiecki Y, Phatak V, Aschauer L, Muller PAJ. Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer. Vol. 11, Frontiers in Oncology. Frontiers Media SA; 2021.Journal
Frontiers in OncologyDOI
10.3389/fonc.2021.804107PubMed ID
35757381Additional Links
https://dx.doi.org/10.3389/fonc.2021.804107Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3389/fonc.2021.804107
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