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    Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer

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    Authors
    von Grabowiecki, Yannick
    Phatak, V.
    Aschauer, L.
    Muller, Patricia
    Affiliation
    Tumour Suppressors Group, Cancer Research United Kingdom (UK) Manchester Institute, The University of Manchester, Macclesfield
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.
    Citation
    von Grabowiecki Y, Phatak V, Aschauer L, Muller PAJ. Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in Cancer. Vol. 11, Frontiers in Oncology. Frontiers Media SA; 2021.
    Journal
    Frontiers in Oncology
    URI
    http://hdl.handle.net/10541/625394
    DOI
    10.3389/fonc.2021.804107
    PubMed ID
    35757381
    Additional Links
    https://dx.doi.org/10.3389/fonc.2021.804107
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fonc.2021.804107
    Scopus Count
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    All Paterson Institute for Cancer Research

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