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    ESTRO ACROP and SIOPE recommendations for myeloablative total body Irradiation in children

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    Authors
    Hoeben, B. A. W.
    Pazos, M.
    Seravalli, E.
    Bosman, M. E.
    Losert, C.
    Albert, M. H.
    Boterberg, T.
    Ospovat, I.
    Mico Milla, S.
    Demiroz Abakay, C.
    Engellau, J.
    Jóhannesson, V.
    Kos, G.
    Supiot, S.
    Llagostera, C.
    Bierings, M.
    Scarzello, G.
    Seiersen, K.
    Smith, Ed
    Ocanto, A.
    Ferrer, C.
    Bentzen, S. M.
    Kobyzeva, D. A.
    Loginova, A. A.
    Janssens, G. O.
    Show allShow less
    Affiliation
    Dept. of Radiation Oncology, University Medical Center Utrecht, The Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Background and purpose: Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially in children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since TBI is associated with multiple late adverse effects, recommendations may help to standardize practices and improve the outcome versus toxicity ratio for children. Material and methods: The European Society for Paediatric Oncology (SIOPE) Radiotherapy TBI Working Group together with ESTRO experts conducted a literature search and evaluation regarding myeloablative TBI techniques and toxicities in children. Findings were discussed in bimonthly virtual meetings and consensus recommendations were established. Results: Myeloablative TBI in HSCT conditioning is mostly performed for high-risk ALL patients or patients with recurring hematologic malignancies. TBI is discouraged in children <3-4 years old because of increased toxicity risk. Publications regarding TBI are mostly retrospective studies with level III-IV evidence. Preferential TBI dose in children is 12-14.4 Gy in 1.6-2 Gy fractions b.i.d. Dose reduction should be considered for the lungs to <8 Gy, for the kidneys to ≤10 Gy, and for the lenses to <12 Gy, for dose rates ≥6 cGy/min. Highly conformal techniques i.e. TomoTherapy and VMAT TBI or Total Marrow (and/or Lymphoid) Irradiation as implemented in several centers, improve dose homogeneity and organ sparing, and should be evaluated in studies. Conclusions: These ESTRO ACROP SIOPE recommendations provide expert consensus for conventional and highly conformal myeloablative TBI in children, as well as a supporting literature overview of TBI techniques and toxicities.
    Citation
    Hoeben BAW, Pazos M, Seravalli E, Bosman ME, Losert C, Albert MH, et al. ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children. Vol. 173, Radiotherapy and Oncology. Elsevier BV; 2022. p. 119–33.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/625356
    DOI
    10.1016/j.radonc.2022.05.027
    PubMed ID
    35661674
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2022.05.027
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2022.05.027
    Scopus Count
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