Bariatric surgery-induced high-density lipoprotein functionality enhancement is associated with reduced inflammation
dc.contributor.author | Adam, Safwaan | |
dc.contributor.author | Ho, J. H. | |
dc.contributor.author | Liu, Y. | |
dc.contributor.author | Siahmansur, T. | |
dc.contributor.author | Siddals, K. | |
dc.contributor.author | Iqbal, Z. | |
dc.contributor.author | Azmi, S. | |
dc.contributor.author | Senapati, S. | |
dc.contributor.author | New, J. | |
dc.contributor.author | Jeziorska, M. | |
dc.contributor.author | Ammori, B. J. | |
dc.contributor.author | Syed, A. A. | |
dc.contributor.author | Donn, R. | |
dc.contributor.author | Malik, R. A. | |
dc.contributor.author | Durrington, P. N. | |
dc.contributor.author | Soran, H. | |
dc.date.accessioned | 2022-06-22T07:18:36Z | |
dc.date.available | 2022-06-22T07:18:36Z | |
dc.date.issued | 2022 | en |
dc.identifier.citation | Adam S, Ho JH, Liu Y, Siahmansur T, Siddals K, Iqbal Z, et al. Bariatric Surgery–induced High-density Lipoprotein Functionality Enhancement Is Associated With Reduced Inflammation. The Journal of Clinical Endocrinology & Metabolism. The Endocrine Society; 2022. | en |
dc.identifier.pmid | 35639942 | en |
dc.identifier.doi | 10.1210/clinem/dgac244 | en |
dc.identifier.uri | http://hdl.handle.net/10541/625339 | |
dc.description.abstract | Background: Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) and reduces inflammation and oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL's capacity to accept cholesterol (cholesterol efflux capacity [CEC]) and active transport through ATP-binding cassette (ABC) A1, G1, and scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly obese subjects on RCT and HDL functionality. Methods: Biomarkers associated with increased CVD risk including tumour necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), myeloperoxidase mass (MPO), PON1 activity, and CEC in vitro were measured in 44 patients before and 6 and 12 months after RYGB. Overweight but otherwise healthy (mean body mass index [BMI] 28 kg/m2) subjects acted as controls. Twelve participants also underwent gluteal subcutaneous adipose tissue biopsies before and 6 months after RYGB for targeted gene expression (ABCA1, ABCG1, SR-B1, TNF-α) and histological analysis (adipocyte size, macrophage density, TNF-α immunostaining). Results: Significant (P < 0.05) improvements in BMI, HDL-cholesterol, hsCRP, TNF-α, MPO mass, PON1 activity, and CEC in vitro were observed after RYGB. ABCG1 (fold-change, 2.24; P = 0.005) and ABCA1 gene expression increased significantly (fold-change, 1.34; P = 0.05). Gluteal fat adipocyte size (P < 0.0001), macrophage density (P = 0.0067), and TNF-α immunostaining (P = 0.0425) were reduced after RYBG and ABCG1 expression correlated inversely with TNF-α immunostaining (r = -0.71; P = 0.03). Conclusion: RYGB enhances HDL functionality in association with a reduction in adipose tissue and systemic inflammation. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1210/clinem/dgac244 | en |
dc.title | Bariatric surgery-induced high-density lipoprotein functionality enhancement is associated with reduced inflammation | en |
dc.type | Article | en |
dc.contributor.department | Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9WU | en |
dc.identifier.journal | Journal of Clinical Endocrinology and Metabolism | en |
dc.description.note | en] |