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    Bariatric surgery-induced high-density lipoprotein functionality enhancement is associated with reduced inflammation

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    Authors
    Adam, Safwaan
    Ho, J. H.
    Liu, Y.
    Siahmansur, T.
    Siddals, K.
    Iqbal, Z.
    Azmi, S.
    Senapati, S.
    New, J.
    Jeziorska, M.
    Ammori, B. J.
    Syed, A. A.
    Donn, R.
    Malik, R. A.
    Durrington, P. N.
    Soran, H.
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    Affiliation
    Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9WU
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Background: Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) and reduces inflammation and oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL's capacity to accept cholesterol (cholesterol efflux capacity [CEC]) and active transport through ATP-binding cassette (ABC) A1, G1, and scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly obese subjects on RCT and HDL functionality. Methods: Biomarkers associated with increased CVD risk including tumour necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), myeloperoxidase mass (MPO), PON1 activity, and CEC in vitro were measured in 44 patients before and 6 and 12 months after RYGB. Overweight but otherwise healthy (mean body mass index [BMI] 28 kg/m2) subjects acted as controls. Twelve participants also underwent gluteal subcutaneous adipose tissue biopsies before and 6 months after RYGB for targeted gene expression (ABCA1, ABCG1, SR-B1, TNF-α) and histological analysis (adipocyte size, macrophage density, TNF-α immunostaining). Results: Significant (P < 0.05) improvements in BMI, HDL-cholesterol, hsCRP, TNF-α, MPO mass, PON1 activity, and CEC in vitro were observed after RYGB. ABCG1 (fold-change, 2.24; P = 0.005) and ABCA1 gene expression increased significantly (fold-change, 1.34; P = 0.05). Gluteal fat adipocyte size (P < 0.0001), macrophage density (P = 0.0067), and TNF-α immunostaining (P = 0.0425) were reduced after RYBG and ABCG1 expression correlated inversely with TNF-α immunostaining (r = -0.71; P = 0.03). Conclusion: RYGB enhances HDL functionality in association with a reduction in adipose tissue and systemic inflammation.
    Citation
    Adam S, Ho JH, Liu Y, Siahmansur T, Siddals K, Iqbal Z, et al. Bariatric Surgery–induced High-density Lipoprotein Functionality Enhancement Is Associated With Reduced Inflammation. The Journal of Clinical Endocrinology &amp; Metabolism. The Endocrine Society; 2022. 
    Journal
    Journal of Clinical Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/625339
    DOI
    10.1210/clinem/dgac244
    PubMed ID
    35639942
    Additional Links
    https://dx.doi.org/10.1210/clinem/dgac244
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1210/clinem/dgac244
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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