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dc.contributor.authorCampana, Luca G
dc.contributor.authorBalestrieri, N.
dc.contributor.authorMenin, N.
dc.date.accessioned2022-06-22T07:18:32Z
dc.date.available2022-06-22T07:18:32Z
dc.date.issued2022en
dc.identifier.citationCampana LG, Balestrieri N, Menin N. Adjuvant skin-sparing electrochemotherapy in a breast cancer patient with a prosthetic implant: 5-year follow-up outcomes. Vol. 2022, Journal of Surgical Case Reports. Oxford University Press (OUP); 2022.en
dc.identifier.pmid35599994en
dc.identifier.doi10.1093/jscr/rjac199en
dc.identifier.urihttp://hdl.handle.net/10541/625324
dc.description.abstractA 55-year-old woman with previous skin-sparing mastectomy and prosthetic reconstruction for multifocal ductal carcinoma developed homolateral axillary recurrence. Following nodal dissection, partial periprosthetic capsulectomy and the overlying breast skin excision, the pathology report revealed a positive cutaneous margin. Since further breast skin excision or radiotherapy would have compromised the prosthetic implant, and the patient was adamant about avoiding any endangering intervention, the multidisciplinary recommendation included skin-directed electrochemotherapy (ECT) in the frame of a multimodal treatment strategy. The procedure lasted 20 minutes under mild general sedation and included a bolus of intravenous bleomycin followed by local application of electric pulses using a needle electrode. The postprocedural course was uneventful, except for mild dermatologic toxicity. At 5 years, the patient is disease-free with the implant in situ. This report illustrates the proof-of-concept of adjuvant skin-sparing ECT to sterilize resection margins, preserve a breast implant and highlight procedural details to avert toxicity.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1093/jscr/rjac199en
dc.titleAdjuvant skin-sparing electrochemotherapy in a breast cancer patient with a prosthetic implant: 5-year follow-up outcomesen
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, The Christie NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalJournal of Surgical Case Reportsen
dc.description.noteen]
refterms.dateFOA2022-06-22T11:51:29Z


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