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    Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

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    Authors
    Macias, R. I. R.
    Cardinale, V.
    Kendall, T. J.
    Avila, M. A.
    Guido, M.
    Coulouarn, C.
    Braconi, C.
    Frampton, A. E.
    Bridgewater, J.
    Overi, D.
    Pereira, S. P.
    Rengo, M.
    Kather, J. N.
    Lamarca, Angela
    Pedica, F.
    Forner, A.
    Valle, Juan W
    Gaudio, E.
    Alvaro, D.
    Banales, J. M.
    Carpino, G.
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    Affiliation
    Experimental Hepatology and Drug Targeting (HEVEPHARM) group, University of Salamanca, IBSAL, Salamanca, Spain
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Cholangiocarcinoma (CCA) is a malignant tumour arising from the biliary system. In Europe, this tumour frequently presents as a sporadic cancer in patients without defined risk factors and is usually diagnosed at advanced stages with a consequent poor prognosis. Therefore, the identification of biomarkers represents an utmost need for patients with CCA. Numerous studies proposed a wide spectrum of biomarkers at tissue and molecular levels. With the present paper, a multidisciplinary group of experts within the European Network for the Study of Cholangiocarcinoma discusses the clinical role of tissue biomarkers and provides a selection based on their current relevance and potential applications in the framework of CCA. Recent advances are proposed by dividing biomarkers based on their potential role in diagnosis, prognosis and therapy response. Limitations of current biomarkers are also identified, together with specific promising areas (ie, artificial intelligence, patient-derived organoids, targeted therapy) where research should be focused to develop future biomarkers.
    Citation
    Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, et al. Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions. Gut. BMJ; 2022.
    Journal
    Gut
    URI
    http://hdl.handle.net/10541/625317
    DOI
    10.1136/gutjnl-2022-327099
    PubMed ID
    35580963
    Additional Links
    https://dx.doi.org/10.1136/gutjnl-2022-327099
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1136/gutjnl-2022-327099
    Scopus Count
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