Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges
Affiliation
Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UKIssue Date
2022
Metadata
Show full item recordAbstract
Cutaneous T-cell lymphoma is a rare type of extranodal non-Hodgkin's lymphoma that primarily affects the skin. The uncertain pathogenesis and variable clinical presentation make the diagnosis and management of cutaneous T-cell lymphoma a challenge. Cutaneous T-cell lymphoma is a chronic, relapsing illness with treatment aimed at symptomatic relief and improving patient related quality of life. Early-stage cutaneous T-cell lymphoma typically follows an indolent course, often being mistaken for benign dermatological conditions which can lead to a diagnostic delay. Advanced stage cutaneous T-cell lymphoma has a poor prognosis with significant morbidity. Accurate diagnosis and early involvement of a specialist team is paramount to ensure correct management and improved patient outcomes. Promising advances are being made to develop novel agents which could improve prognosis and quality of life. This article provides an overview of the two main subtypes of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Clinical presentation, histopathological correlation and diagnostic challenges are reviewed alongside example case studies.Citation
Hague C, Farquharson N, Menasce L, Parry E, Cowan R. Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges. Vol. 83, British Journal of Hospital Medicine. Mark Allen Group; 2022. p. 1–7.Journal
British Journal of Hospital MedicineDOI
10.12968/hmed.2021.0149PubMed ID
35506718Additional Links
https://dx.doi.org/10.12968/hmed.2021.0149Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.12968/hmed.2021.0149