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    Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges

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    Authors
    Hague, Christina
    Farquharson, N.
    Menasce, Lia P
    Parry, E.
    Cowan, Richard A
    Affiliation
    Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Cutaneous T-cell lymphoma is a rare type of extranodal non-Hodgkin's lymphoma that primarily affects the skin. The uncertain pathogenesis and variable clinical presentation make the diagnosis and management of cutaneous T-cell lymphoma a challenge. Cutaneous T-cell lymphoma is a chronic, relapsing illness with treatment aimed at symptomatic relief and improving patient related quality of life. Early-stage cutaneous T-cell lymphoma typically follows an indolent course, often being mistaken for benign dermatological conditions which can lead to a diagnostic delay. Advanced stage cutaneous T-cell lymphoma has a poor prognosis with significant morbidity. Accurate diagnosis and early involvement of a specialist team is paramount to ensure correct management and improved patient outcomes. Promising advances are being made to develop novel agents which could improve prognosis and quality of life. This article provides an overview of the two main subtypes of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Clinical presentation, histopathological correlation and diagnostic challenges are reviewed alongside example case studies.
    Citation
    Hague C, Farquharson N, Menasce L, Parry E, Cowan R. Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges. Vol. 83, British Journal of Hospital Medicine. Mark Allen Group; 2022. p. 1–7.
    Journal
    British Journal of Hospital Medicine
    URI
    http://hdl.handle.net/10541/625293
    DOI
    10.12968/hmed.2021.0149
    PubMed ID
    35506718
    Additional Links
    https://dx.doi.org/10.12968/hmed.2021.0149
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.12968/hmed.2021.0149
    Scopus Count
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