• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Morgan.pdf
    Size:
    862.2Kb
    Format:
    PDF
    Description:
    Identified with Open Access button
    Download
    Authors
    Morgan, J. L.
    Cheng, V.
    Barry, P. A.
    Copson, E.
    Cutress, R. I.
    Dave, R.
    Elsberger, B.
    Fairbrother, P.
    Hartup, S.
    Hogan, B.
    Horgan, K.
    Kirwan, Cliona C
    McIntosh, S. A.
    O'Connell, R. L.
    Patani, N.
    Potter, S.
    Rattay, T.
    Sheehan, L.
    Wyld, L.
    Kim, B.
    Show allShow less
    Affiliation
    Department of Oncology and Metabolism, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Introduction: Evidence based guidelines for the optimal management of breast cancer locoregional recurrence (LRR) are limited, with potential for variation in clinical practice. This national practice questionnaire (NPQ) was designed to establish the current practice of UK breast multidisciplinary teams (MDTs) regarding LRR management. Methods: UK breast units were invited to take part in the MARECA study MDT NPQ. Scenario-based questions were used to elicit preference in pre-operative staging investigations, surgical management, and adjuvant therapy. Results: 822 MDT members across 42 breast units (out of 144; 29%) participated in the NPQ (February-August 2021). Most units (95%) routinely performed staging CT scan, but bone scan was selectively performed (31%). For patients previously treated with breast conserving surgery (BCS) and radiotherapy, few units (7%) always/usually offered repeat BCS. However, in the absence of radiotherapy, most units (90%) always/usually offered repeat BCS. For patients presenting with isolated local recurrence following previous BCS and SLNB (sentinel lymph node biopsy), most units (95%) advocated repeat SLNB. Where SLNs could not be identified, 86% proceeded to a four-node axillary sampling procedure. For ER positive, HER2 negative, node negative local recurrence, 10% of units always/usually offered chemotherapy. For ER positive, HER2 negative, node positive local recurrence, this recommendation increased to 64%. For triple negative breast cancer local recurrence, 90% of units always/usually offered chemotherapy. Conclusion: This survey has highlighted where consistencies and variations exist in the multidisciplinary management of breast cancer LRR. However, further research is required to determine how these management patterns influence patient outcomes, which will further refine optimal treatment pathways.
    Citation
    Morgan JL, Cheng V, Barry PA, Copson E, Cutress RI, Dave R, et al. The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making. European Journal of Surgical Oncology. Elsevier BV; 2022.
    Journal
    European Journal of Surgical Oncology
    URI
    http://hdl.handle.net/10541/625291
    DOI
    10.1016/j.ejso.2022.03.017
    PubMed ID
    35410760
    Additional Links
    https://dx.doi.org/10.1016/j.ejso.2022.03.017
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejso.2022.03.017
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Sentinel lymph node biopsy following previous axillary surgery in recurrent breast cancer.
    • Authors: Sávolt Á, Cserni G, Lázár G, Maráz R, Kelemen P, Kovács E, Győrffy B, Udvarhelyi N, Vörös A, Ormándi K, Mátrai Z
    • Issue date: 2019 Oct
    • Second axillary sentinel node biopsy for ipsilateral breast tumour recurrence.
    • Authors: Intra M, Trifirò G, Galimberti V, Gentilini O, Rotmensz N, Veronesi P
    • Issue date: 2007 Oct
    • Repeat sentinel lymph node biopsy in patients with ipsilateral recurrent breast cancer after breast-conserving therapy and negative sentinel lymph node biopsy: a prospective study.
    • Authors: Folli S, Falco G, Mingozzi M, Buggi F, Curcio A, Ferrari G, Taffurelli M, Regolo L, Nanni O
    • Issue date: 2016 Apr
    • Feasibility and oncological safety of sentinel node biopsy in breast cancer patients with a local recurrence.
    • Authors: Biglia N, Bounous VE, Gallo M, Fuso L, Sgro LG, Maggiorotto F, Ponzone R
    • Issue date: 2018 Oct
    • Nodal Recurrence in Patients With Node-Positive Breast Cancer Treated With Sentinel Node Biopsy Alone After Neoadjuvant Chemotherapy-A Rare Event.
    • Authors: Barrio AV, Montagna G, Mamtani A, Sevilimedu V, Edelweiss M, Capko D, Cody HS 3rd, El-Tamer M, Gemignani ML, Heerdt A, Kirstein L, Moo TA, Pilewskie M, Plitas G, Sacchini V, Sclafani L, Tadros A, Van Zee KJ, Morrow M
    • Issue date: 2021 Dec 1
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.