The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making
Authors
Morgan, J. L.Cheng, V.
Barry, P. A.
Copson, E.
Cutress, R. I.
Dave, R.
Elsberger, B.
Fairbrother, P.
Hartup, S.
Hogan, B.
Horgan, K.
Kirwan, Cliona C
McIntosh, S. A.
O'Connell, R. L.
Patani, N.
Potter, S.
Rattay, T.
Sheehan, L.
Wyld, L.
Kim, B.
Affiliation
Department of Oncology and Metabolism, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UKIssue Date
2022
Metadata
Show full item recordAbstract
Introduction: Evidence based guidelines for the optimal management of breast cancer locoregional recurrence (LRR) are limited, with potential for variation in clinical practice. This national practice questionnaire (NPQ) was designed to establish the current practice of UK breast multidisciplinary teams (MDTs) regarding LRR management. Methods: UK breast units were invited to take part in the MARECA study MDT NPQ. Scenario-based questions were used to elicit preference in pre-operative staging investigations, surgical management, and adjuvant therapy. Results: 822 MDT members across 42 breast units (out of 144; 29%) participated in the NPQ (February-August 2021). Most units (95%) routinely performed staging CT scan, but bone scan was selectively performed (31%). For patients previously treated with breast conserving surgery (BCS) and radiotherapy, few units (7%) always/usually offered repeat BCS. However, in the absence of radiotherapy, most units (90%) always/usually offered repeat BCS. For patients presenting with isolated local recurrence following previous BCS and SLNB (sentinel lymph node biopsy), most units (95%) advocated repeat SLNB. Where SLNs could not be identified, 86% proceeded to a four-node axillary sampling procedure. For ER positive, HER2 negative, node negative local recurrence, 10% of units always/usually offered chemotherapy. For ER positive, HER2 negative, node positive local recurrence, this recommendation increased to 64%. For triple negative breast cancer local recurrence, 90% of units always/usually offered chemotherapy. Conclusion: This survey has highlighted where consistencies and variations exist in the multidisciplinary management of breast cancer LRR. However, further research is required to determine how these management patterns influence patient outcomes, which will further refine optimal treatment pathways.Citation
Morgan JL, Cheng V, Barry PA, Copson E, Cutress RI, Dave R, et al. The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making. European Journal of Surgical Oncology. Elsevier BV; 2022.Journal
European Journal of Surgical OncologyDOI
10.1016/j.ejso.2022.03.017PubMed ID
35410760Additional Links
https://dx.doi.org/10.1016/j.ejso.2022.03.017Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.ejso.2022.03.017
Scopus Count
Collections
Related articles
- The NeST (Neoadjuvant systemic therapy in breast cancer) study: National Practice Questionnaire of United Kingdom multi-disciplinary decision making.
- Authors: Whitehead I, Irwin GW, Bannon F, Coles CE, Copson E, Cutress RI, Dave RV, Gardiner MD, Grayson M, Holcombe C, Irshad S, O'Brien C, O'Connell RL, Palmieri C, Shaaban AM, Sharma N, Singh JK, Potter S, McIntosh SA, NeST Study Research Collaborative.
- Issue date: 2021 Jan 22
- Locoregional therapy of locally advanced breast cancer: a clinical practice guideline.
- Authors: Brackstone M, Fletcher GG, Dayes IS, Madarnas Y, SenGupta SK, Verma S, Members of the Breast Cancer Disease Site Group.
- Issue date: 2015 Mar
- Axillary treatment for operable primary breast cancer.
- Authors: Bromham N, Schmidt-Hansen M, Astin M, Hasler E, Reed MW
- Issue date: 2017 Jan 4
- Sentinel lymph node biopsy following previous axillary surgery in recurrent breast cancer.
- Authors: Sávolt Á, Cserni G, Lázár G, Maráz R, Kelemen P, Kovács E, Győrffy B, Udvarhelyi N, Vörös A, Ormándi K, Mátrai Z
- Issue date: 2019 Oct
- Nodal Recurrence in Patients With Node-Positive Breast Cancer Treated With Sentinel Node Biopsy Alone After Neoadjuvant Chemotherapy-A Rare Event.
- Authors: Barrio AV, Montagna G, Mamtani A, Sevilimedu V, Edelweiss M, Capko D, Cody HS 3rd, El-Tamer M, Gemignani ML, Heerdt A, Kirstein L, Moo TA, Pilewskie M, Plitas G, Sacchini V, Sclafani L, Tadros A, Van Zee KJ, Morrow M
- Issue date: 2021 Dec 1