Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
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Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.Issue Date
2021
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Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.Citation
Simeoni F, Somervaille TC. Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. Vol. 8, Molecular & Cellular Oncology. Informa UK Limited; 2021.Journal
Molecular and Cellular OncologyDOI
10.1080/23723556.2021.2003161PubMed ID
35419467Additional Links
https://dx.doi.org/10.1080/23723556.2021.2003161Type
OtherLanguage
enae974a485f413a2113503eed53cd6c53
10.1080/23723556.2021.2003161
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