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    Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

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    Authors
    Simeoni, Fabrizio
    Somervaille, Tim C P
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
    Issue Date
    2021
    
    Metadata
    Show full item record
    Abstract
    Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.
    Citation
    Simeoni F, Somervaille TC. Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. Vol. 8, Molecular & Cellular Oncology. Informa UK Limited; 2021.
    Journal
    Molecular and Cellular Oncology
    URI
    http://hdl.handle.net/10541/625286
    DOI
    10.1080/23723556.2021.2003161
    PubMed ID
    35419467
    Additional Links
    https://dx.doi.org/10.1080/23723556.2021.2003161
    Type
    Other
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1080/23723556.2021.2003161
    Scopus Count
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