Pathways from diagnosis to death from keratinocyte cancer in kidney transplant recipients
AffiliationQIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
MetadataShow full item record
AbstractBackground: Kidney transplant recipients are at increased risk of developing and dying from keratinocyte cancer. We aimed to describe the clinical course of keratinocyte cancer-related deaths in a cohort of kidney transplant recipients. Methods: In kidney transplant recipients transplanted between 1995 and 2014 in Queensland, Australia, we ascertained keratinocyte cancer deaths by searching national transplant and state death registries to March 2020. Deceased transplant recipients' medical records were reviewed to assess features of the primary lesion of the fatal keratinocyte cancer, metastases, and clinical information before death. Results: Of 658 kidney transplant recipient deaths, 49 (7%) were due to keratinocyte cancer, and medical records were available for 36 (73%). One death was due to basal cell carcinoma, and 35 were from squamous cell carcinoma (SCC), primarily from the head and neck (24; 69%). The most common site of metastasis was the lungs (21; 58%). Median time (minimum, maximum) from the diagnosis of primary SCC to metastasis was 5 months (0, 29). After this, the median time to death was 9 months (1, 50). Conclusion: Fatal keratinocyte cancers overwhelmingly arise on the head and neck, with lungs the most common metastasis site. The short time from diagnosis of primary to death indicates the aggressive nature of these keratinocyte cancers.
CitationShao EX, Khosrotehrani K, Campbell S, Isbel N, Green A. Pathways from Diagnosis to Death from Keratinocyte Cancer in Kidney Transplant Recipients. Dermatology. S. Karger AG; 2022. p. 1–8.
- Keratinocyte Cancer Mortality in Kidney Transplant Recipients.
- Authors: Shao EX, Betz-Stablein B, Khosrotehrani K, Campbell S, Isbel N, Green AC
- Issue date: 2022 May 1
- Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients.
- Authors: Letellier T, Le Borgne F, Kerleau C, Gaultier A, Dantal J, Ville S, Divat Consortium.
- Issue date: 2020 Dec 7
- Higher mycophenolate dosage is associated with an increased risk of squamous cell carcinoma in kidney transplant recipients.
- Authors: Shao EX, Betz-Stablein B, Marquat L, Campbell S, Isbel N, Green AC, Plasmeijer EI
- Issue date: 2022 Aug 19
- Voriconazole and the Risk of Keratinocyte Carcinomas Among Lung Transplant Recipients in the United States.
- Authors: D'Arcy ME, Pfeiffer RM, Rivera DR, Hess GP, Cahoon EK, Arron ST, Brownell I, Cowen EW, Israni AK, Triplette MA, Yanik EL, Engels EA
- Issue date: 2020 Jul 1
- Diagnostic Delays for Non-melanoma Skin Cancers in Renal Transplant Recipients during the COVID-19 Pandemic: What is Hiding Behind the Mask?
- Authors: Mokos M, Bašić-Jukić N
- Issue date: 2021 Jul