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    Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

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    Authors
    Eyden, Brian P
    Ru, Y. X.
    Dong, S. X.
    Liu, J.
    Liu, X. F.
    Affiliation
    Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2021
    
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    Abstract
    Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases; however, the details of the mechanism leading to low platelet count remain elusive. Megakaryocytes are a series of progenitor cells responsible for the production of platelets. Alterations in megakaryocytes in the bone marrow are a causative factor resulting in thrombocytopenia in varied diseases. Based on ultrastructural analysis of incidentally encountered megakaryocytes in 43 patients with blood diseases marked by low platelet counts, electron micrographs demonstrated that aberrant megakaryocytes predominated in idiopathic thrombocytopenic purpura, aplastic anemia, and myelodysplastic syndrome; autophagy, apoptosis, and cellular damage in megakaryocytes were a prominent feature in aplastic anemia. On the other hand, poorly differentiated megakaryocytes predominated in acute megakaryoblastic leukemia (AMKL) although damaged megakaryocytes were seen in non-AMKL acute leukemia. This paper documents the ultrastructural alterations of megakaryocytes associated with thrombocytopenia and reveals distinctive features for particular blood diseases. A comment is made on future avenues of research emphasizing membrane fusion proteins.
    Citation
    Eyden B, Ru YX, Dong SX, Liu J, Liu XF. Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases. Vol. 3, Blood Science. Ovid Technologies (Wolters Kluwer Health); 2021. p. 107–12.
    Journal
    Blood Science
    URI
    http://hdl.handle.net/10541/625274
    DOI
    10.1097/bs9.0000000000000093
    PubMed ID
    35402843
    Additional Links
    https://dx.doi.org/10.1097/bs9.0000000000000093
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1097/bs9.0000000000000093
    Scopus Count
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