• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    35418701.pdf
    Size:
    1.290Mb
    Format:
    PDF
    Description:
    Identified with Open Access button
    Download
    Authors
    Wang, X.
    Kapoor, P. M.
    Auer, P. L.
    Dennis, J.
    Dunning, A. M.
    Wang, Q.
    Lush, M.
    Michailidou, K.
    Bolla, M. K.
    Aronson, K. J.
    Murphy, R. A.
    Brooks-Wilson, A.
    Lee, D. G.
    Cordina-Duverger, E.
    Guénel, P.
    Truong, T.
    Mulot, C.
    Teras, L. R.
    Patel, A. V.
    Dossus, L.
    Kaaks, R.
    Hoppe, R.
    Lo, W. Y.
    Brüning, T.
    Hamann, U.
    Czene, K.
    Gabrielson, M.
    Hall, P.
    Eriksson, M.
    Jung, A.
    Becher, H.
    Couch, F. J.
    Larson, N. L.
    Olson, J. E.
    Ruddy, K. J.
    Giles, G. G.
    MacInnis, R. J.
    Southey, M. C.
    Le Marchand, L.
    Wilkens, L. R.
    Haiman, C. A.
    Olsson, H.
    Augustinsson, A.
    Krüger, U.
    Wagner, P.
    Scott, C.
    Winham, S. J.
    Vachon, C. M.
    Perou, C. M.
    Olshan, A. F.
    Troester, M. A.
    Hunter, D. J.
    Eliassen, H. A.
    Tamimi, R. M.
    Brantley, K.
    Andrulis, I. L.
    Figueroa, J.
    Chanock, S. J.
    Ahearn, T. U.
    García-Closas, M.
    Evans, G. D.
    Newman, W. G.
    van Veen, E. M.
    Howell, Anthony
    Wolk, A.
    Håkansson, N.
    Anton-Culver, H.
    Ziogas, A.
    Jones, M. E.
    Orr, N.
    Schoemaker, M. J.
    Swerdlow, A. J.
    Kitahara, C. M.
    Linet, M.
    Prentice, R. L.
    Easton, D. F.
    Milne, R. L.
    Kraft, P.
    Chang-Claude, J.
    Lindström, S.
    Show allShow less
    Affiliation
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values < 5 × 10-8 as genome-wide significant, and p-values < 1 × 10-5 as suggestive. Linkage disequilibrium (LD)-based clumping was performed to identify independent candidate variants. of the 9.7 million genetic variants tested for interactions with MHT use reached genome-wide significance. Only 213 variants, representing 18 independent loci, had p-values < 1 × 105. The strongest evidence was found for rs4674019 (p-value = 2.27 × 10-7), which showed genome-wide significant interaction (p-value = 3.8 × 10-8) with current MHT use when analysis was restricted to population-based studies only. Limiting the analyses to combined estrogen-progesterone MHT use only or to estrogen receptor (ER) positive cases did not identify any genome-wide significant evidence of interactions. In this large genome-wide SNP-MHT interaction study of breast cancer, we found no strong support for common genetic variants modifying the effect of MHT on breast cancer risk. These results suggest that common genetic variation has limited impact on the observed MHT-breast cancer risk association.
    Citation
    Wang X, Kapoor PM, Auer PL, Dennis J, Dunning AM, Wang Q, et al. Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women. Vol. 12, Scientific Reports. Springer Science and Business Media LLC; 2022.
    Journal
    Scientific Reports
    URI
    http://hdl.handle.net/10541/625266
    DOI
    10.1038/s41598-022-10121-2
    PubMed ID
    35418701
    Additional Links
    https://dx.doi.org/10.1038/s41598-022-10121-2
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-022-10121-2
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication.
    • Authors: Hein R, Flesch-Janys D, Dahmen N, Beckmann L, Lindström S, Schoof N, Czene K, Mittelstraß K, Illig T, Seibold P, Behrens S, Humphreys K, Li J, Liu J, Olson JE, Wang X, Hankinson SE, Truong T, Menegaux F, Dos Santos Silva I, Johnson N, GENICA Network, Chen ST, Yu JC, Ziogas A, Kataja V, Kosma VM, Mannermaa A, Anton-Culver H, Shen CY, Brauch H, Peto J, Guénel P, Kraft P, Couch FJ, Easton DF, Hall P, Chang-Claude J
    • Issue date: 2013 Apr
    • Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study.
    • Authors: DeBono NL, Robinson WR, Lund JL, Tse CK, Moorman PG, Olshan AF, Troester MA
    • Issue date: 2018 Mar
    • Menopausal Hormone Therapy use and breast cancer risk by receptor subtypes: Results from the New South Wales Cancer Lifestyle and EvaluAtion of Risk (CLEAR) study.
    • Authors: Salagame U, Banks E, O'Connell DL, Egger S, Canfell K
    • Issue date: 2018
    • Interactions between breast cancer susceptibility loci and menopausal hormone therapy in relationship to breast cancer in the Breast and Prostate Cancer Cohort Consortium.
    • Authors: Gaudet MM, Barrdahl M, Lindström S, Travis RC, Auer PL, Buring JE, Chanock SJ, Eliassen AH, Gapstur SM, Giles GG, Gunter M, Haiman C, Hunter DJ, Joshi AD, Kaaks R, Khaw KT, Lee IM, Le Marchand L, Milne RL, Peeters PH, Sund M, Tamimi R, Trichopoulou A, Weiderpass E, Yang XR, Prentice RL, Feigelson HS, Canzian F, Kraft P
    • Issue date: 2016 Feb
    • Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
    • Authors: Rudolph A, Hein R, Lindström S, Beckmann L, Behrens S, Liu J, Aschard H, Bolla MK, Wang J, Truong T, Cordina-Duverger E, Menegaux F, Brüning T, Harth V, GENICA Network, Severi G, Baglietto L, Southey M, Chanock SJ, Lissowska J, Figueroa JD, Eriksson M, Humpreys K, Darabi H, Olson JE, Stevens KN, Vachon CM, Knight JA, Glendon G, Mulligan AM, Ashworth A, Orr N, Schoemaker M, Webb PM, kConFab Investigators, AOCS Management Group, Guénel P, Brauch H, Giles G, García-Closas M, Czene K, Chenevix-Trench G, Couch FJ, Andrulis IL, Swerdlow A, Hunter DJ, Flesch-Janys D, Easton DF, Hall P, Nevanlinna H, Kraft P, Chang-Claude J, Breast Cancer Association Consortium
    • Issue date: 2013 Dec
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.