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    Current status and future directions of immunotherapies in soft tissue sarcomas

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    Authors
    Kerrison, W. G. J.
    Lee, Alexander T
    Thway, K.
    Jones, R. L.
    Huang, P. H.
    Affiliation
    Division of Molecular Pathology, The Institute of Cancer Research, Sutton SM2 5NG, UK
    Issue Date
    2022
    
    Metadata
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    Abstract
    Immunotherapy in soft tissue sarcoma (STS) has experienced a surge of interest in the past decade, contributing to an expanding number of therapeutic options for this extremely heterogenous group of rare malignancies. Immune checkpoint inhibitors (CPIs) targeting the PD-1 and CTLA-4 axes have demonstrated promising responses in a select number of STS subtypes, including rarer subtypes, such as alveolar soft part sarcoma, SWI/SNF-deficient sarcomas, clear cell sarcoma, and angiosarcoma. Multiple pan-subtype sarcoma trials have facilitated the study of possible predictive biomarkers of the CPI response. It has also become apparent that certain therapies, when combined with CPIs, can enhance response rates, although the specific mechanisms of this possible synergy remain unconfirmed in STS. In addition to CPIs, several other immune targeting agents, including anti-tumour-associated macrophage and antigen-directed therapies, are now under assessment in STS with promising efficacy in some subtypes. In this article, we review the state of the art in immunotherapy in STS, highlighting the pre-clinical and clinical data available for this promising therapeutic strategy.
    Citation
    Kerrison WGJ, Lee ATJ, Thway K, Jones RL, Huang PH. Current Status and Future Directions of Immunotherapies in Soft Tissue Sarcomas. Vol. 10, Biomedicines. MDPI AG; 2022. p. 573.
    Journal
    Biomedicines
    URI
    http://hdl.handle.net/10541/625262
    DOI
    10.3390/biomedicines10030573
    PubMed ID
    35327375
    Additional Links
    https://dx.doi.org/10.3390/biomedicines10030573
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/biomedicines10030573
    Scopus Count
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