• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    SARON: stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer (NSCLC)

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Mak, K. M.
    McDonald, F.
    Teague, J.
    Faivre-Finn, C.
    Forster, M.
    Hanna, G.
    Moinuddin, S.
    Conibear, J.
    Harden, S.
    Popat, S.
    Califano, R.
    Farrelly, L.
    Counsell, N.
    Saron, T. M. G.
    Show allShow less
    Affiliation
    CR UK & UCL Cancer Trials Centre, London,
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Oligometastatic NSCLC patients have better outcomes than those with the higher disease burden associated with wider spread metastatic disease. SABR/SRS have been extensively reported to result in excellent local control of individual metastatic deposits with low rates of grade 3+ toxicity. SARON is a randomised controlled phase-III trial to investigate the impact of conventional RT and SABR/SRS in oligometastatic NSCLC patients suitable for radical treatment (maximum of 5 metastases involving a maximum of 3 organs, in-line with the recent EORTC consensus definition of synchronous oligometastatic disease). SARON is a multi-centre, randomised-controlled trial (RCT) with an original target sample size of 340. Patients are randomised in 1:1 ratio to standard of care (SOC) alone or SOC plus radiotherapy to all disease sites. SOC in the UK in this patient population is systemic anti-cancer therapy (SACT): mono-chemotherapy, mono-immunotherapy or combination of chemo-immunotherapy, chosen according to standard guidelines. SARON opened for recruitment in 08/2016; 20 centres are open to date (06/12/2021) with 136 patients registered, 89 randomised. Following initial recruitment difficulties due to the changing landscape of SOC treatment and the subsequent impact of the pandemic, we are in the process of implementing a protocol amendment to change the design from a phase-III RCT to a practice informing phase-II RCT. The subsequent reduction in required sample size to 134 randomised patients, whilst keeping a primary endpoint of overall survival, will ensure that the study objectives remain scientifically relevant at the expected time of reporting in early 2026. In addition to the significance level and power being relaxed, original assumptions regarding estimates for median overall survival in the control arm following the change to SACT and length of recruitment period have been re-estimated. In moving to a phase-II design, SARON will remain an important clinical trial that will help guiding management of this complex patient population.
    Citation
    Mak KM, McDonald F, Teague J, Faivre-Finn C, Forster M, Hanna G, et al. SARON: stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer (NSCLC). Vol. 165, Lung Cancer. Elsevier BV; 2022. p. S71.
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/625252
    DOI
    10.1016/s0169-5002(22)00202-1
    Additional Links
    https://dx.doi.org/10.1016/s0169-5002(22)00202-1
    Type
    Meetings and Proceedings
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/s0169-5002(22)00202-1
    Scopus Count
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.