• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Fankhauser, Christian D
    de Vries, H. M.
    Roussel, E.
    Jakobsen, J. K.
    Issa, Allaudin
    Lee, Esther
    Schifano, N.
    Alnajjar, H.
    Castiglione, F.
    Antonelli, L.
    Oliveira, Pedro
    Lau, Maurice W
    Parnham, Arie S
    Albersen, M.
    Watkin, N. A.
    Muneer, A.
    Ayres, B. E.
    Brouwer, O. R.
    Sangar, Vijay K W
    Show allShow less
    Affiliation
    Department of Urology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Purpose: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. Methods: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. Results: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17). Conclusion: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.
    Citation
    Fankhauser CD, de Vries HM, Roussel E, Jakobsen JK, Issa A, Lee EWC, et al. Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer. Journal of Cancer Research and Clinical Oncology. Springer Science and Business Media LLC; 2022.
    Journal
    Journal of Cancer Research and Clinical Oncology
    URI
    http://hdl.handle.net/10541/625218
    DOI
    10.1007/s00432-022-04012-2
    PubMed ID
    35411405
    Additional Links
    https://dx.doi.org/10.1007/s00432-022-04012-2
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00432-022-04012-2
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • High diagnostic accuracy of inguinal ultrasonography and fine-needle aspiration followed by dynamic sentinel lymph node biopsy in men with impalpable and palpable inguinal lymph nodes.
    • Authors: Lee EWC, Issa A, Oliveira P, Lau M, Sangar V, Parnham A, Fankhauser CD
    • Issue date: 2022 Sep
    • Analysis of the related risk factors of inguinal lymph node metastasis in patients with penile cancer: A cross-sectional study.
    • Authors: Jia Y, Zhao H, Hao Y, Zhu J, Li Y, Wang Y
    • Issue date: 2022 Mar-Apr
    • Prognostic factors for occult inguinal lymph node involvement in penile carcinoma and assessment of the high-risk EAU subgroup: a two-institution analysis of 342 clinically node-negative patients.
    • Authors: Graafland NM, Lam W, Leijte JA, Yap T, Gallee MP, Corbishley C, van Werkhoven E, Watkin N, Horenblas S
    • Issue date: 2010 Nov
    • Management of the lymph nodes in penile cancer.
    • Authors: Heyns CF, Fleshner N, Sangar V, Schlenker B, Yuvaraja TB, van Poppel H
    • Issue date: 2010 Aug
    • Reliability of radioisotope-guided sentinel lymph node biopsy in penile cancer: verification in consideration of the European guidelines.
    • Authors: Schubert T, Uphoff J, Henke RP, Wawroschek F, Winter A
    • Issue date: 2015 Sep 28
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.