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dc.contributor.authorConway, Alicia-Marie
dc.contributor.authorMorris, G. C.
dc.contributor.authorSmith, Sarah
dc.contributor.authorVekeria, Monique
dc.contributor.authorManoharan, Prakash
dc.contributor.authorMitchell, Claire L
dc.contributor.authorBacken, Alison C
dc.contributor.authorOliveira, Pedro
dc.contributor.authorHubner, Richard A
dc.contributor.authorLamarca, Angela
dc.contributor.authorMcNamara, Mairead G
dc.contributor.authorValle, Juan W
dc.contributor.authorCook, Natalie
dc.date.accessioned2022-05-26T08:34:58Z
dc.date.available2022-05-26T08:34:58Z
dc.date.issued2022en
dc.identifier.citationConway AM, Morris GC, Smith S, Vekeria M, Manoharan P, Mitchell C, et al. Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary. British Journal of Cancer. Springer Science and Business Media LLC; 2022.en
dc.identifier.pmid35484217en
dc.identifier.doi10.1038/s41416-022-01824-4en
dc.identifier.urihttp://hdl.handle.net/10541/625216
dc.description.abstractBackground: Many patients referred with a provisional diagnosis of cancer of unknown primary (pCUP) present with presumed metastatic disease to the liver. Due to the lack of definitive histological markers, intrahepatic cholangiocarcinoma (iCCA) may be overlooked. This study assessed the frequency of iCCA within a pCUP cohort. Methods: A single UK cancer-center study of sequential patients referred with pCUP from January 2017 to April 2020. Baseline diagnostic imaging was reviewed independently by a radiologist and oncologist; those with radiological features of iCCA (dominant liver lesion, capsular retraction) were identified. Results: Of 228 patients referred with pCUP, 72 (32%) had malignancy involving the liver. 24/72 patients had radiological features consistent with iCCA; they were predominantly female (75%) with an average age of 63 years and 63% had an ECOG PS ≤ 2. The median overall survival (OS) of the iCCA group and the remaining liver-involved CUP group were similar (OS 4.1 vs 4.4 months, p-value = 0.805). Patients, where a primary diagnosis was subsequently determined, had better OS (10.2 months, p-values: iCCA = 0.0279: cCUP = 0.0230). Conclusions: In this study, 34% of patients with liver-involved pCUP, fulfilled the radiological criteria for an iCCA diagnosis. Consideration of an iCCA diagnosis in patients with CUP could improve timely diagnosis, molecular characterisation and treatment.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41416-022-01824-4en
dc.titleIntrahepatic cholangiocarcinoma hidden within cancer of unknown primaryen
dc.typeArticleen
dc.contributor.departmentCancer Research UK Manchester Institute Cancer Biomarker Centre, The University of Manchester, Manchester, UKen
dc.identifier.journalBritish Journal of Canceren
dc.description.noteen]
refterms.dateFOA2022-06-28T14:16:28Z


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