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    A preclinical radiotherapy dosimetry audit using a realistic 3D printed murine phantom

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    Authors
    Biglin, Emma R
    Aitkenhead, Adam H
    Price, Gareth J
    Chadwick, Amy
    Santina, Elham
    Williams, K. J.
    Kirkby, Karen J
    Affiliation
    Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.
    Issue Date
    2022
    
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    Abstract
    Preclinical radiation research lacks standardized dosimetry procedures that provide traceability to a primary standard. Consequently, ensuring accuracy and reproducibility between studies is challenging. Using 3D printed murine phantoms we undertook a dosimetry audit of Xstrahl Small Animal Radiation Research Platforms (SARRPs) installed at 7 UK centres. The geometrically realistic phantom accommodated alanine pellets and Gafchromic EBT3 film for simultaneous measurement of the dose delivered and the dose distribution within a 2D plane, respectively. Two irradiation scenarios were developed: (1) a 10 × 10 mm2 static field targeting the pelvis, and (2) a 5 × 5 mm2 90° arc targeting the brain. For static fields, the absolute difference between the planned dose and alanine measurement across all centres was 4.1 ± 4.3% (mean ± standard deviation), with an overall range of - 2.3 to 10.5%. For arc fields, the difference was - 1.2% ± 6.1%, with a range of - 13.1 to 7.7%. EBT3 dose measurements were greater than alanine by 2.0 ± 2.5% and 3.5 ± 6.0% (mean ± standard deviation) for the static and arc fields, respectively. 2D dose distributions showed discrepancies to the planned dose at the field edges. The audit demonstrates that further work on preclinical radiotherapy quality assurance processes is merited.
    Citation
    Biglin ER, Aitkenhead AH, Price GJ, Chadwick AL, Santina E, Williams KJ, et al. A preclinical radiotherapy dosimetry audit using a realistic 3D printed murine phantom. Vol. 12, Scientific Reports. Springer Science and Business Media LLC; 2022.
    Journal
    Scientific Reports
    URI
    http://hdl.handle.net/10541/625212
    DOI
    10.1038/s41598-022-10895-5
    PubMed ID
    35474242
    Additional Links
    https://dx.doi.org/10.1038/s41598-022-10895-5
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-022-10895-5
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