• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Impact of introducing intensity-modulated radiotherapy (IMRT) on curative intent radiotherapy and survival for lung cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Chan, Clara
    Fornacon-Wood, Isabella
    Bayman, Neil A
    Banfill, Kathryn
    Coote, Joanna H
    Garbett, Alexander
    Harris, Maggie A
    Hudson, Andrew M
    Kennedy, Jason
    Pemberton, Laura S
    Price, Gareth J
    Salem, Ahmed
    Sheikh, Hamid Y
    Whitehurst, Philip
    Woolf, David K
    Faivre-Finn, Corinne
    Show allShow less
    Affiliation
    The Christie NHS Foundation Trust, Manchester
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Introduction: Lung cancer survival remains poor. Intensity-modulated radiotherapy (IMRT) has allowed treatment of more complex tumours as it improves radiotherapy dose conformity around the tumour and greater normal tissue sparing. However, there is limited evidence in the literature assessing the clinical impact of IMRT. In this study, we evaluated whether the introduction of IMRT has influenced the proportion of patients treated with curative-intent radiotherapy over time, and patient survival. Methods: Patients treated with thoracic radiotherapy at our institute between 2005-2020 were retrospectively identified and grouped into three time periods: A) 2005-2008 (pre-IMRT), B) 2009-2012 (some availability IMRT), and C) 2013-2020 (full access IMRT). Data on performance status (PS), stage, age, gross tumour volume (GTV) and survival were collected. The proportion of patients treated with a curative dose between these periods was compared. Multivariable survival models were fitted to evaluate the hazard for patients treated in each time period, adjusting for PS, stage, age and tumour volume. Results: 12,499 patients were included in the analysis (n=2675 (A), n=3127 (B), and n=6697 (C)). The proportion of patients treated with curative-intent radiotherapy increased between the 3 time periods, from 38.1% to 50.2% to 65.6% (p<0.001). This trend was seen across all PS and stages. The GTV increased across time periods. Curative-intent patients treated during period C had a survival improvement compared to time period A (HR=0.725 (0.632-0.831), p<0.001). Conclusion: The introduction of IMRT was associated with more patients receiving curative-intent radiotherapy across all PS and stages of disease. It also facilitated the treatment of larger tumours that historically would have been treated palliatively. Despite treating larger tumours, a survival benefit was seen when full access to IMRT was available (2013-2020). This study highlights the impact IMRT has had on our practice, accepting that improved survival may also be attributed to other contributing factors.
    Citation
    Chan C, Fornacon-Wood I, Bayman N, Banfil K, Coote J, Garbett A, et al. Impact of introducing intensity modulated radiotherapy (IMRT) on curative intent radiotherapy and survival for lung cancer. Vol. 165, Lung Cancer. Elsevier BV; 2022. p. S49.
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/625208
    DOI
    10.1016/S0169-5002(22)00151-9
    Additional Links
    https://dx.doi.org/10.1016/S0169-5002(22)00151-9
    Type
    Meetings and Proceedings
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0169-5002(22)00151-9
    Scopus Count
    Collections
    All Christie Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.