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    BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing?

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    Authors
    Morgan, Robert David
    Burghel, GJ
    Flaum, Nicola
    Bulman, M
    Smith, P
    Clamp, Andrew R
    Hasan, Jurjees
    Mitchell, Claire L
    Salih, Zena
    Woodward, E R
    Lalloo, F
    Crosbie, EJ
    Edmondson, RJ
    Wallace, AJ
    Jayson, G. C.
    Evans, D G R
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    Affiliation
    The Christie NHS Foundation Trust, Manchester
    Issue Date
    2022
    
    Metadata
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    Abstract
    National guidelines recommend testing all cases of non-mucinous epithelial ovarian cancer (NMEOC) for germline (blood) and somatic (tumour) BRCA1/2 pathogenic variants (PVs). We performed paired germline and somatic BRCA1/2 testing in consecutive cases of NMEOC (n = 388) to validate guidelines. Thirty-four somatic BRCA1/2 (sBRCA) PVs (9.7%) were detected in 350 cases with germline BRCA1/2 (gBRCA) wild-type. All sBRCA PVs were detected in non-familial cases. By analysing our regional germline BRCA1/2 database there were 92/1114 (8.3%) gBRCA PVs detected in non-familial cases (only 3% ≥70 years old) and 245/641 (38.2%) in familial cases. Germline non-familial cases were dominated by BRCA2 in older women (8/271 ≥ 70 years old, all BRCA2). The ratio of sBRCA-to-gBRCA was ≤1.0 in women aged <70 years old, compared to 5.2 in women aged ≥70 years old (P = 0.005). The likelihood of missed germline BRCA1/2 PVs (copy-number variants missed on most somatic assays) by testing only tumour DNA was 0.4% in women aged ≥70 years old. We recommend reflex tumour BRCA1/2 testing in all NMEOC cases, and that gBRCA testing is not required for women aged ≥70 years old with no identifiable tumour BRCA1/2 PV and/or family history of breast, ovarian, prostate and/or pancreatic cancer.
    Citation
    Morgan, R D, Burghel, G J, Flaum, N, Bulman, M, Smith, P, Clamp, A R, Hasan, J, Mitchell, C L, Salih, Z, Woodward, E R, Lalloo, F, Crosbie, E J, Edmondson, R J, Wallace, A J, Jayson, G C, Evans, D G R. BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing? British Journal of Cancer. 2022 Mar 8
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/625202
    DOI
    10.1038/s41416-022-01773-y
    PubMed ID
    35260807
    Additional Links
    https://dx.doi.org/10.1038/s41416-022-01773-y
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-022-01773-y
    Scopus Count
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    All Christie Publications

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