Work-Up and Outcome of Hepatic Resection for Peri-Hilar Cholangiocarcinoma (PH-CCA) without Staging Laparoscopy
dc.contributor.author | Jegatheeswaran, S. | |
dc.contributor.author | Stathakis, P. | |
dc.contributor.author | Spiers, H. V. M. | |
dc.contributor.author | Mohammed, F. | |
dc.contributor.author | Petras, P. | |
dc.contributor.author | Satyadas, T. | |
dc.contributor.author | Parker, M. J. | |
dc.contributor.author | Lamarca, Angela | |
dc.contributor.author | Jamdar, S. | |
dc.contributor.author | Sheen, A. J. | |
dc.contributor.author | Siriwardena, A. K. | |
dc.date.accessioned | 2022-04-28T13:57:49Z | |
dc.date.available | 2022-04-28T13:57:49Z | |
dc.date.issued | 2022 | en |
dc.identifier.citation | Jegatheeswaran S, Stathakis P, Spiers HVM, Mohammed F, Petras P, Satyadas T, et al. Work-Up and Outcome of Hepatic Resection for Peri-Hilar Cholangiocarcinoma (PH-CCA) without Staging Laparoscopy. Cancers. 2022;14(7):12. | en |
dc.identifier.doi | 10.3390/cancers14071841 | en |
dc.identifier.uri | http://hdl.handle.net/10541/625187 | |
dc.description.abstract | Background: This study reports the outcome of a work-up programme for resection of peri-hilar cholangiocarcinoma (PH-CCA) without the use of staging laparoscopy. Methods: This is a clinical case cohort series of patients undergoing surgical resection of PH-CCA without the use of staging laparoscopy in the work-up algorithm. During the 13 years from 1 January 2009 to 1 January 2022, 32 patients underwent laparotomy for planned surgical resection of PH-CCA. Data were collected on demographic profile, admission biochemistry, radiology, pre-operative intervention, operation and outcome, together with post-operative complications and disease-free and overall survival. Results: All patients underwent pre-operative contrast-enhanced CT. Twenty-four (75%) underwent pre-operative MR. Twenty-three (72%) underwent pre-operative biliary drainage. Twenty-nine patients (91%) had either type III or IV peri-hilar cholangiocarcinoma. One patient (3%) in this series underwent a non-resectional laparotomy. Twenty-nine (91%) had a final histopathological diagnosis of PH-CCA. One further patient had a final diagnosis of an intraductal papillary neoplasm of the biliary tree (IPNB) with high-grade dysplasia but no invasive cancer. Eleven patients (36%) received chemotherapy after surgery. The median (95% CI) time to recurrence was 14 (7–31) months. The median survival was 25 (18-upper limit not reached) months. Conclusion: This cohort of 32 patients undergoing attempted resection for PH-CCA without the use of staging laparoscopy in the work-up algorithm indicates that with careful attention to patient fitness and cross-sectional and interventional radiologic/endoscopic imaging, a very low non-therapeutic laparotomy rate of 3% can be achieved and sustained. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.3390/cancers14071841 | en |
dc.title | Work-Up and Outcome of Hepatic Resection for Peri-Hilar Cholangiocarcinoma (PH-CCA) without Staging Laparoscopy | en |
dc.type | Article | en |
dc.identifier.journal | Cancers | en |
dc.description.note | en] | |
refterms.dateFOA | 2022-06-28T11:59:47Z |