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    Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer

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    Authors
    Nalio Ramos, R.
    Missolo-Koussou, Y.
    Gerber-Ferder, Y.
    Bromley, C. P.
    Bugatti, M.
    Núñez, N. G.
    Tosello Boari, J.
    Richer, W.
    Menger, L.
    Denizeau, J.
    Sedlik, C.
    Caudana, P.
    Kotsias, F.
    Niborski, L. L.
    Viel, S.
    Bohec, M.
    Lameiras, S.
    Baulande, S.
    Lesage, L.
    Nicolas, A.
    Meseure, D.
    Vincent-Salomon, A.
    Reyal, F.
    Dutertre, C. A.
    Ginhoux, F.
    Vimeux, L.
    Donnadieu, E.
    Buttard, B.
    Galon, J.
    Zelenay, S.
    Vermi, W.
    Guermonprez, P.
    Piaggio, E.
    Helft, J.
    Show allShow less
    Issue Date
    2022
    
    Metadata
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    Abstract
    Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.
    Citation
    Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, et al. Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer. Cell. 2022;185(7):1189-207.e25.
    Journal
    Cell
    URI
    http://hdl.handle.net/10541/625183
    DOI
    10.1016/j.cell.2022.02.021
    PubMed ID
    35325594
    Additional Links
    https://dx.doi.org/10.1016/j.cell.2022.02.021
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2022.02.021
    Scopus Count
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    All Paterson Institute for Cancer Research

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