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    Targeted Therapies for Perihilar Cholangiocarcinoma

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    Authors
    Gray, Simon
    Lamarca, Angela
    Edeline, J.
    Klumpen, H. J.
    Hubner, Richard A
    McNamara, Mairead G
    Valle, Juan W
    Issue Date
    2022
    
    Metadata
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    Abstract
    Perihilar cholangiocarcinoma (pCCA) is the anatomical sub-group of biliary tract cancer (BTC) arising between the second-order intrahepatic bile ducts and the cystic duct. Together with distal and intrahepatic cholangiocarcinoma (dCCA and iCCA; originating distal to, and proximal to this, respectively), gallbladder cancer (GBC) and ampulla of Vater carcinoma (AVC), these clinicopathologically and molecularly distinct entities comprise biliary tract cancer (BTC). Most pCCAs are unresectable at diagnosis, and for those with resectable disease, surgery is extensive, and recurrence is common. Therefore, the majority of patients with pCCA will require systemic treatment for advanced disease. The prognosis with cytotoxic chemotherapy remains poor, driving interest in therapies targeted to the molecular nature of a given patient’s cancer. In recent years, the search for efficacious targeted therapies has been fuelled both by whole-genome and epigenomic studies, looking to uncover the molecular landscape of CCA, and by specifically testing for aberrations where established therapies exist in other indications. This review aims to provide a focus on the current molecular characterisation of pCCA, targeted therapies applicable to pCCA, and future directions in applying personalised medicine to this difficult-to-treat malignancy.
    Citation
    Gray S, Lamarca A, Edeline J, Klumpen HJ, Hubner RA, McNamara MG, et al. Targeted Therapies for Perihilar Cholangiocarcinoma. Cancers. 2022;14(7):19.
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/625181
    DOI
    10.3390/cancers14071789
    PubMed ID
    35406560
    Additional Links
    https://dx.doi.org/10.3390/cancers14071789
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers14071789
    Scopus Count
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