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    Early detection of cancer

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    Authors
    Crosby, D.
    Bhatia, S.
    Brindle, K. M.
    Coussens, L. M.
    Dive, Caroline
    Emberton, M.
    Esener, S.
    Fitzgerald, R. C.
    Gambhir, S. S.
    Kuhn, P.
    Rebbeck, T. R.
    Balasubramanian, S.
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    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.
    Citation
    Crosby D, Bhatia S, Brindle KM, Coussens LM, Dive C, Emberton M, et al. Early detection of cancer. Vol. 375, Science. American Association for the Advancement of Science (AAAS); 2022.
    Journal
    Science
    URI
    http://hdl.handle.net/10541/625161
    DOI
    10.1126/science.aay9040
    PubMed ID
    35298272
    Additional Links
    https://dx.doi.org/10.1126/science.aay9040
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.aay9040
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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