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dc.contributor.authorFrancavilla, C.
dc.contributor.authorO'Brien, C. S.
dc.date.accessioned2022-03-09T13:35:20Z
dc.date.available2022-03-09T13:35:20Z
dc.date.issued2022en
dc.identifier.citationFrancavilla C, O’Brien CS. Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer [Internet]. Vol. 12, Open Biology. The Royal Society; 2022.en
dc.identifier.doi10.1098/rsob.210373en
dc.identifier.urihttp://hdl.handle.net/10541/625111
dc.description.abstractFibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF ligands and signalling partners are often dysregulated in breast cancer progression and are one of the causes of resistance to treatment in breast cancer. Furthermore, FGFR signalling on epithelial cells is affected by signals from the breast microenvironment, therefore increasing the possibility of breast developmental abnormalities or cancer progression. Increasing our understanding of the multi-layered roles of the complex family of FGFRs, their ligands FGFs and their regulatory partners may offer novel treatment strategies for breast cancer patients, as a single agent or rational co-target, which will be explored in depth in this review.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1098/rsob.210373en
dc.titleFibroblast growth factor receptor signalling dysregulation and targeting in breast canceren
dc.typeArticleen
dc.identifier.journalOpen Biologyen
dc.description.noteen]
refterms.dateFOA2022-06-27T12:44:13Z


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