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    Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer

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    Authors
    Francavilla, C.
    O'Brien, C. S.
    Issue Date
    2022
    
    Metadata
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    Abstract
    Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF ligands and signalling partners are often dysregulated in breast cancer progression and are one of the causes of resistance to treatment in breast cancer. Furthermore, FGFR signalling on epithelial cells is affected by signals from the breast microenvironment, therefore increasing the possibility of breast developmental abnormalities or cancer progression. Increasing our understanding of the multi-layered roles of the complex family of FGFRs, their ligands FGFs and their regulatory partners may offer novel treatment strategies for breast cancer patients, as a single agent or rational co-target, which will be explored in depth in this review.
    Citation
    Francavilla C, O’Brien CS. Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer [Internet]. Vol. 12, Open Biology. The Royal Society; 2022.
    Journal
    Open Biology
    URI
    http://hdl.handle.net/10541/625111
    DOI
    10.1098/rsob.210373
    Additional Links
    https://dx.doi.org/10.1098/rsob.210373
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1098/rsob.210373
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