• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Clinico-pathological predictors of clinical complete response in rectal cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    MbanuP.pdf
    Size:
    2.058Mb
    Format:
    PDF
    Description:
    Identified with Open Access button
    Download
    Authors
    Mbanu, Peter
    Vasquez Osorio, Eliana
    Mistry, H.
    Malcomson, Lee
    Yousif, S.
    Aznar, Marianne Camille
    Kochhar, Rohit
    Van-Herk, Marcel
    Renehan, Andrew G
    Saunders, Mark P
    Affiliation
    Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom. Electronic address: Peter.mbanu1@nhs.net. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Division of Pharmacy, University of Manchester, Manchester, United Kingdom. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; Colorectal and Peritoneal Oncology Centre, Christie NHS Foundation Trust, Manchester, United Kingdom. Department of Clinical Oncology, Lancashire Teaching Hospital, Preston, United Kingdom. Department of Radiological Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom. Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom.
    Issue Date
    2022
    
    Metadata
    Show full item record
    Abstract
    Purpose Prediction of clinical complete response in rectal cancer before neoadjuvant chemo-radiotherapy treatment enables treatment selection. Patients predicted to have complete response could have chemo-radiotherapy, and others could have additional doublet chemotherapy at this stage of their treatment to improve their overall outcome. This work investigates the role of clinical variables in predicting clinical complete response. Method Using the UK-based OnCoRe database (2008 to 2019), we performed a propensity-score matched study of 322 patients who received neoadjuvant chemoradiotherapy. We collected pre-treatment clinic-pathological, inflammatory and radiotherapy-related characteristics. We determined the odds for the occurrence of cCR using conditional logistic regression models. We derived the post-model Area under the Curve (AUC) as an indicator of discrimination performance and stated a priori that an AUC of 0.75 or greater was required for potential clinical utility. Results Pre-treatment tumour diameter, mrT-stage, haemoglobin, alkaline phosphate and total radiotherapy depths were associated with cCR on univariable and multivariable analysis. Additionally, neutrophil to lymphocyte ratio (NLR), neutrophil-monocyte to lymphocyte ratio (NMLR), lymphocyte count and albumin were all significantly associated with cCR on multivariable analysis. A nomogram using the above parameters was developed with a resulting ROC AUC of 0.75. Conclusion We identified routine clinic-pathological, inflammatory and radiotherapy-related variables which are independently associated with cCR. A nomogram was developed to predict cCR. The performance characteristics from this model were on the prior clinical utility threshold. Additional research is required to develop more associated variables to better select patients with rectal cancer undergoing chemoradiotherapy who may benefit from pursuing a W&W strategy.
    Citation
    Mbanu P, Osorio EV, Mistry H, Malcomson L, Yousif S, Aznar M, et al. Clinico-pathological predictors of clinical complete response in rectal cancer [Internet]. Vol. 31, Cancer Treatment and Research Communications. Elsevier BV; 2022. p. 100540.
    Journal
    Cancer Treat Res Commun
    URI
    http://hdl.handle.net/10541/625100
    DOI
    10.1016/j.ctarc.2022.100540
    PubMed ID
    35231874
    Additional Links
    https://dx.doi.org/10.1016/j.ctarc.2022.100540
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctarc.2022.100540
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • A multicentre cohort study assessing the utility of routine blood tests as adjuncts to identify complete responders in rectal cancer following neoadjuvant chemoradiotherapy.
    • Authors: Eastern Rectal Cancer Response Collaborative, Ireland
    • Issue date: 2022 Apr
    • A single institution's long-term follow-up of patients with pathological complete response in locally advanced rectal adenocarcinoma following neoadjuvant chemoradiotherapy.
    • Authors: Runau F, Collins A, Fenech GA, Ford E, Dimitriou N, Chaudhri S, Yeung JM
    • Issue date: 2017 Mar
    • [Analysis on efficacy and safety of total neoadjuvant therapy in patients with locally advanced rectal cancer with high risk factors].
    • Authors: Ouyang GL, Meng WJ, Shu P, Deng XB, Wu B, Jiang D, Zhuang H, Shen YL, Zhou ZG, Wang ZQ, Wang X
    • Issue date: 2019 Apr 25
    • Predicting Pathological Complete Regression with Haematological Markers During Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
    • Authors: Lee JH, Song C, Kang SB, Lee HS, Lee KW, Kim JS
    • Issue date: 2018 Dec
    • [Rectum-preserving surgery after consolidation neoadjuvant therapy or totally neoadjuvant therapy for low rectal cancer: a preliminary report].
    • Authors: Huang Y, Huang SH, Chi P, Wang XJ, Lin HM, Lu XR, Ye DX, Lin Y, Deng Y
    • Issue date: 2020 Mar 25
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.