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dc.contributor.authorLee, E. W. C.
dc.contributor.authorIssa, A.
dc.contributor.authorOliveira, P.
dc.contributor.authorLau, M.
dc.contributor.authorSangar, V.
dc.contributor.authorParnham, A.
dc.contributor.authorFankhauser, C. D.
dc.date.accessioned2022-02-22T11:44:39Z
dc.date.available2022-02-22T11:44:39Z
dc.date.issued2022en
dc.identifier.citationLee EWC, Issa A, Oliveira P, Lau M, Sangar V, Parnham A, et al. High diagnostic accuracy of inguinal ultrasonography and fine needle aspiration followed by dynamic sentinel lymph node biopsy in men with non‐palpable and palpable inguinal lymph nodes. BJU International. Wiley; 2022.en
dc.identifier.pmid35098622en
dc.identifier.doi10.1111/bju.15700en
dc.identifier.urihttp://hdl.handle.net/10541/625066
dc.description.abstractObjectives To assess the accuracy of dynamic sentinel lymph node biopsy (DSNB) after negative ultrasonography (US) guided fine needle aspiration (FNA) for ILN staging. Subjects/patients and methods We performed a retrospective analysis of men with ≥T1G2 penile cancer and negative inguinal US guided FNA undergoing DSNB. Men with suspicious US but negative FNA underwent US guided ILN excision. Men with ≥T1G2 local recurrence during follow-up and non-squamous cell histologies were excluded. Descriptive analysis was performed, and sensitivity and negative predictive values (NPV) were calculated. Results We included 403 men with 728 groins with negative FNA undergoing DSNB +/- US guided lymph node excision. At least one sentinel node (SN) was visualised in 93% during the 1st and in 7% during the 2nd lymphoscintigraphy. Median SNs visualised preoperatively was 1 and a median of 2 nodes were resected. ILN metastases were detected in 9% groins in men with non-palpable and in 17% men with palpable lymph nodes. Stratified by non-palpable and palpable ILN, non-local recurrence despite pathologically negative DSNBs was observed in 0.5% and 0%. Limited to men with at least 24 months follow-up, non-local recurrence after negative DSNBs was observed in 0.4% and 0%. The sensitivity of DSNB was 96% and NPV was 100%. The main limitation of this analysis is its retrospective nature with inherit biases. Conclusions Inguinal US and FNA followed by DSNB can accurately stage men with both non-palpable and palpable ILN which provides logistical and surgical advantages.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1111/bju.15700en
dc.titleHigh diagnostic accuracy of inguinal ultrasonography and fine needle aspiration followed by dynamic sentinel lymph node biopsy in men with non-palpable and palpable inguinal lymph nodesen
dc.typeArticleen
dc.contributor.departmentThe Christie NHS Foundation Trusts, Manchester, UK. Luzerner Kantonsspital, Luzern, Switzerland. University of Zurich, Zurich, Switzerland.en
dc.identifier.journalBJU Internationalen
dc.description.noteen]


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